The role of regulatory T cells and microglia in glioblastoma-associated immunosuppression.
J Neurooncol
; 123(3): 405-12, 2015 Jul.
Article
en En
| MEDLINE
| ID: mdl-26123363
ABSTRACT
Cell-mediated suppression of anti-tumor immunity is multifactorial in patients with cancer, and recent studies have focused on several distinct cellular agents that are associated with this phenomenon. This review will focus on the potential role of regulatory T cells (Tregs) and microglia in the suppression of cellular immunity observed in patients with glioblastoma. We discuss the ontogeny, basic biology, evidence for activity, and potential clinical options for targeting Tregs and microglia as part of immunotherapy in affected patients.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Encefálicas
/
Terapia de Inmunosupresión
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Linfocitos T Reguladores
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Microglía
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Glioblastoma
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
J Neurooncol
Año:
2015
Tipo del documento:
Article
País de afiliación:
Estados Unidos