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Increased neuronal PreP activity reduces Aß accumulation, attenuates neuroinflammation and improves mitochondrial and synaptic function in Alzheimer disease's mouse model.
Fang, Du; Wang, Yongfu; Zhang, Zhihua; Du, Heng; Yan, Shiqiang; Sun, Qinru; Zhong, Changjia; Wu, Long; Vangavaragu, Jhansi Rani; Yan, Shijun; Hu, Gang; Guo, Lan; Rabinowitz, Molly; Glaser, Elzbieta; Arancio, Ottavio; Sosunov, Alexander A; McKhann, Guy M; Chen, John Xi; Yan, Shirley ShiDu.
Afiliación
  • Fang D; Department of Pharmacology and Toxicology, Higuchi Bioscience Center, School of Pharmacy, University of Kansas, Lawrence, KS 66047, USA.
  • Wang Y; Department of Pharmacology and Toxicology, Higuchi Bioscience Center, School of Pharmacy, University of Kansas, Lawrence, KS 66047, USA.
  • Zhang Z; Department of Pharmacology and Toxicology, Higuchi Bioscience Center, School of Pharmacy, University of Kansas, Lawrence, KS 66047, USA, School of Life Sciences, Beijing Normal University, Beijing 100871, China.
  • Du H; Department of Pharmacology and Toxicology, Higuchi Bioscience Center, School of Pharmacy, University of Kansas, Lawrence, KS 66047, USA.
  • Yan S; Taub Institute for Research on Alzheimer's disease and the Aging Brain, New York, NY 10032, USA.
  • Sun Q; Department of Pharmacology and Toxicology, Higuchi Bioscience Center, School of Pharmacy, University of Kansas, Lawrence, KS 66047, USA.
  • Zhong C; Department of Pharmacology and Toxicology, Higuchi Bioscience Center, School of Pharmacy, University of Kansas, Lawrence, KS 66047, USA.
  • Wu L; Department of Pharmacology and Toxicology, Higuchi Bioscience Center, School of Pharmacy, University of Kansas, Lawrence, KS 66047, USA.
  • Vangavaragu JR; Department of Pharmacology and Toxicology, Higuchi Bioscience Center, School of Pharmacy, University of Kansas, Lawrence, KS 66047, USA.
  • Yan S; Department of Pharmacology and Toxicology, Higuchi Bioscience Center, School of Pharmacy, University of Kansas, Lawrence, KS 66047, USA.
  • Hu G; Department of Pharmacology and Toxicology, Higuchi Bioscience Center, School of Pharmacy, University of Kansas, Lawrence, KS 66047, USA.
  • Guo L; Department of Pharmacology and Toxicology, Higuchi Bioscience Center, School of Pharmacy, University of Kansas, Lawrence, KS 66047, USA.
  • Rabinowitz M; Taub Institute for Research on Alzheimer's disease and the Aging Brain, New York, NY 10032, USA.
  • Glaser E; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
  • Arancio O; Taub Institute for Research on Alzheimer's disease and the Aging Brain, New York, NY 10032, USA.
  • Sosunov AA; Department of Neurosurgery, Physicians & Surgeons College of Columbia University, New York, NY 10032, USA and.
  • McKhann GM; Department of Neurosurgery, Physicians & Surgeons College of Columbia University, New York, NY 10032, USA and.
  • Chen JX; Department of Neurology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
  • Yan SS; Department of Pharmacology and Toxicology, Higuchi Bioscience Center, School of Pharmacy, University of Kansas, Lawrence, KS 66047, USA, shidu@ku.edu.
Hum Mol Genet ; 24(18): 5198-210, 2015 Sep 15.
Article en En | MEDLINE | ID: mdl-26123488

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sinapsis / Serina Endopeptidasas / Péptidos beta-Amiloides / Enfermedad de Alzheimer / Agregación Patológica de Proteínas / Mitocondrias / Neuronas Límite: Animals Idioma: En Revista: Hum Mol Genet Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sinapsis / Serina Endopeptidasas / Péptidos beta-Amiloides / Enfermedad de Alzheimer / Agregación Patológica de Proteínas / Mitocondrias / Neuronas Límite: Animals Idioma: En Revista: Hum Mol Genet Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos