Implications of understanding the signaling, cellular, and cytotoxic mechanisms afforded by afucosylated antibodies.
Oncoimmunology
; 4(6): e1009288, 2015 Jun.
Article
en En
| MEDLINE
| ID: mdl-26155429
ABSTRACT
Afucosylated antibodies potentiate natural killer (NK) cell-mediated antibody-dependent cellular cytotoxicity (ADCC) by enhancing signaling pathways and cellular processes, which in turn, increases cytotoxic potential. Importantly, a better understanding of these processes and properties will aid in exploiting them to help design therapeutic antibodies and strategies that may be of the greatest benefit to patients.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Oncoimmunology
Año:
2015
Tipo del documento:
Article
País de afiliación:
Estados Unidos