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T(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26.
Meller, Stephan; Di Domizio, Jeremy; Voo, Kui S; Friedrich, Heike C; Chamilos, Georgios; Ganguly, Dipyaman; Conrad, Curdin; Gregorio, Josh; Le Roy, Didier; Roger, Thierry; Ladbury, John E; Homey, Bernhard; Watowich, Stanley; Modlin, Robert L; Kontoyiannis, Dimitrios P; Liu, Yong-Jun; Arold, Stefan T; Gilliet, Michel.
Afiliación
  • Meller S; 1] Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. [2] Department of Dermatology, Heinrich-Heine-University Medical Faculty, Düsseldorf, Germany.
  • Di Domizio J; Department of Dermatology, University Hospital CHUV, Lausanne, Switzerland.
  • Voo KS; Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Friedrich HC; Department of Dermatology, Heinrich-Heine-University Medical Faculty, Düsseldorf, Germany.
  • Chamilos G; 1] Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. [2] Department of Infectious Diseases, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Ganguly D; Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Conrad C; Department of Dermatology, University Hospital CHUV, Lausanne, Switzerland.
  • Gregorio J; Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Le Roy D; Department of Infectious Diseases, University Hospital CHUV, Lausanne, Switzerland.
  • Roger T; Department of Infectious Diseases, University Hospital CHUV, Lausanne, Switzerland.
  • Ladbury JE; School of Molecular and Cell Biology, University of Leeds, Leeds, UK.
  • Homey B; Department of Dermatology, Heinrich-Heine-University Medical Faculty, Düsseldorf, Germany.
  • Watowich S; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA.
  • Modlin RL; Division of Dermatology, UCLA David Geffen School of Medicine, Los Angeles, California, USA.
  • Kontoyiannis DP; Department of Infectious Diseases, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  • Liu YJ; Department of Respiratory, Inflammation and Autoimmunity, MedImmune, Gaithersburg, Maryland, USA.
  • Arold ST; Division of Biological and Environmental Sciences &Engineering, King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia.
  • Gilliet M; 1] Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. [2] Department of Dermatology, University Hospital CHUV, Lausanne, Switzerland.
Nat Immunol ; 16(9): 970-9, 2015 Sep.
Article en En | MEDLINE | ID: mdl-26168081
ABSTRACT
Interleukin 17-producing helper T cells (T(H)17 cells) have a major role in protection against infections and in mediating autoimmune diseases, yet the mechanisms involved are incompletely understood. We found that interleukin 26 (IL-26), a human T(H)17 cell-derived cytokine, is a cationic amphipathic protein that kills extracellular bacteria via membrane-pore formation. Furthermore, T(H)17 cell-derived IL-26 formed complexes with bacterial DNA and self-DNA released by dying bacteria and host cells. The resulting IL-26-DNA complexes triggered the production of type I interferon by plasmacytoid dendritic cells via activation of Toll-like receptor 9, but independently of the IL-26 receptor. These findings provide insights into the potent antimicrobial and proinflammatory function of T(H)17 cells by showing that IL-26 is a natural human antimicrobial that promotes immune sensing of bacterial and host cell death.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: ADN / ADN Bacteriano / Interleucinas / Receptor Toll-Like 9 / Células Th17 / Inmunidad Innata Límite: Animals / Humans Idioma: En Revista: Nat Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: ADN / ADN Bacteriano / Interleucinas / Receptor Toll-Like 9 / Células Th17 / Inmunidad Innata Límite: Animals / Humans Idioma: En Revista: Nat Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Alemania