Shocking therapy: Brief electrical stimulation for delayed nerve repair.
Exp Neurol
; 271: 524-5, 2015 Sep.
Article
en En
| MEDLINE
| ID: mdl-26206729
ABSTRACT
This commentary provides perspective on a recent paper published in Experimental Neurology by Elzinga et al. where the authors investigated the effect of brief electrical stimulation (ES) on nerve regeneration after delayed nerve repair in a rodent model. Their results from a well controlled series of experiments indicated that brief ES promoted axonal outgrowth after chronic axotomy as well after chronic Schwann cell and muscle denervation. ES also increased chronically axotomized neurons regenerating into chronically denervated stumps, which represent a true delayed repair. The authors conclude that brief ES promotion of nerve regeneration after delayed nerve repair is as effective as after immediate repair. Given the prior experimental evidence, and the prior clinical data from patients with carpal tunnel syndrome and digital nerve repair, the implication of this new work is to consider a well designed clinical trial for use of brief ES in nerve graft and nerve transfer repairs.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Estimulación Eléctrica
/
Traumatismos de los Nervios Periféricos
/
Regeneración Nerviosa
Tipo de estudio:
Clinical_trials
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Exp Neurol
Año:
2015
Tipo del documento:
Article
País de afiliación:
Canadá