Characterization of P4 ATPase Phospholipid Translocases (Flippases) in Human and Rat Pancreatic Beta Cells: THEIR GENE SILENCING INHIBITS INSULIN SECRETION.

Ansari, Israr-ul H; Longacre, Melissa J; Paulusma, Coen C; Stoker, Scott W; Kendrick, Mindy A; MacDonald, Michael J

Ansari, Israr-ul H; Longacre, Melissa J; Paulusma, Coen C; Stoker, Scott W; Kendrick, Mindy A; MacDonald, Michael J.

Afiliación

Ansari IU; From the Childrens Diabetes Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706 and.
Longacre MJ; From the Childrens Diabetes Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706 and.
Paulusma CC; the Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, 1105 BK Amsterdam, The Netherlands.
Stoker SW; From the Childrens Diabetes Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706 and.
Kendrick MA; From the Childrens Diabetes Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706 and.
MacDonald MJ; From the Childrens Diabetes Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706 and mjmacdon@wisc.edu.

J Biol Chem ; 290(38): 23110-23, 2015 Sep 18.

Article en En | MEDLINE | ID: mdl-26240149

Asunto(s)

Adenosina Trifosfatasas/metabolismo; Membrana Celular/enzimología; Células Secretoras de Insulina/metabolismo; Insulina/metabolismo; Proteínas de Transferencia de Fosfolípidos/metabolismo; Adenosina Trifosfatasas/genética; Animales; Línea Celular; Membrana Celular/genética; Silenciador del Gen; Humanos; Insulina/genética; Secreción de Insulina; Células Secretoras de Insulina/citología; Proteínas de la Membrana/genética; Proteínas de la Membrana/metabolismo; Fosfatidilserinas/genética; Fosfatidilserinas/metabolismo; Proteínas de Transferencia de Fosfolípidos/genética; Ratas

Palabras clave

P4 ATPases; beta cell (B-cell); gene silencing; human pancreatic islets; insulin exocytosis; insulin secretion; insulin secretory vesicles; phosphatidylserine; phospholipid; phospholipid translocases

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Membrana Celular / Adenosina Trifosfatasas / Proteínas de Transferencia de Fosfolípidos / Células Secretoras de Insulina / Insulina Límite: Animals / Humans Idioma: En Revista: J Biol Chem Año: 2015 Tipo del documento: Article

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