Detection of trans-cis flips and peptide-plane flips in protein structures.
Acta Crystallogr D Biol Crystallogr
; 71(Pt 8): 1604-14, 2015 Aug.
Article
en En
| MEDLINE
| ID: mdl-26249342
ABSTRACT
A coordinate-based method is presented to detect peptide bonds that need correction either by a peptide-plane flip or by a trans-cis inversion of the peptide bond. When applied to the whole Protein Data Bank, the method predicts 4617 trans-cis flips and many thousands of hitherto unknown peptide-plane flips. A few examples are highlighted for which a correction of the peptide-plane geometry leads to a correction of the understanding of the structure-function relation. All data, including 1088 manually validated cases, are freely available and the method is available from a web server, a web-service interface and through WHAT_CHECK.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Péptidos
/
Proteínas
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Acta Crystallogr D Biol Crystallogr
Año:
2015
Tipo del documento:
Article
País de afiliación:
Países Bajos