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Tissue-Engineering Approaches to Restore Kidney Function.
Katari, Ravi; Edgar, Lauren; Wong, Theresa; Boey, Angela; Mancone, Sarah; Igel, Daniel; Callese, Tyler; Voigt, Marcia; Tamburrini, Riccardo; Zambon, Joao Paulo; Perin, Laura; Orlando, Giuseppe.
Afiliación
  • Katari R; Section of Transplantation, Department of Surgery, Wake Forest School of Medicine, Winston Salem, NC, USA.
Curr Diab Rep ; 15(10): 69, 2015 Oct.
Article en En | MEDLINE | ID: mdl-26275443
ABSTRACT
Kidney transplantation for the treatment of chronic kidney disease has established outcome and quality of life. However, its implementation is severely limited by a chronic shortage of donor organs; consequently, most candidates remain on dialysis and on the waiting list while accruing further morbidity and mortality. Furthermore, those patients that do receive kidney transplants are committed to a life-long regimen of immunosuppressive drugs that also carry significant adverse risk profiles. The disciplines of tissue engineering and regenerative medicine have the potential to produce alternative therapies which circumvent the obstacles posed by organ shortage and immunorejection. This review paper describes some of the most promising tissue-engineering solutions currently under investigation for the treatment of acute and chronic kidney diseases. The various stem cell therapies, whole embryo transplantation, and bioengineering with ECM scaffolds are outlined and summarized.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trasplante de Riñón / Ingeniería de Tejidos / Enfermedades Renales Límite: Animals / Humans Idioma: En Revista: Curr Diab Rep Asunto de la revista: ENDOCRINOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trasplante de Riñón / Ingeniería de Tejidos / Enfermedades Renales Límite: Animals / Humans Idioma: En Revista: Curr Diab Rep Asunto de la revista: ENDOCRINOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos