Familial cortical dysplasia caused by mutation in the mammalian target of rapamycin regulator NPRL3.
Ann Neurol
; 79(1): 132-7, 2016 Jan.
Article
en En
| MEDLINE
| ID: mdl-26285051
ABSTRACT
We describe first cousin sibling pairs with focal epilepsy, one of each pair having focal cortical dysplasia (FCD) IIa. Linkage analysis and whole-exome sequencing identified a heterozygous germline frameshift mutation in the gene encoding nitrogen permease regulator-like 3 (NPRL3). NPRL3 is a component of GAP Activity Towards Rags 1, a negative regulator of the mammalian target of rapamycin complex 1 signaling pathway. Immunostaining of resected brain tissue demonstrated mammalian target of rapamycin activation. Screening of 52 unrelated individuals with FCD identified 2 additional patients with FCDIIa and germline NPRL3 mutations. Similar to DEPDC5, NPRL3 mutations may be considered as causal variants in patients with FCD or magnetic resonance imaging-negative focal epilepsy.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Epilepsias Parciales
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Proteínas Activadoras de GTPasa
/
Epilepsia
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Malformaciones del Desarrollo Cortical de Grupo I
Tipo de estudio:
Prognostic_studies
Límite:
Child
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Child, preschool
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Female
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Humans
/
Male
Idioma:
En
Revista:
Ann Neurol
Año:
2016
Tipo del documento:
Article
País de afiliación:
Australia