Structural analysis of CXCR4 - Antagonist interactions using saturation-transfer double-difference NMR.

Cox, Bryan D; Mehta, Anil K; DiRaddo, John O; Liotta, Dennis C; Wilson, Lawrence J; Snyder, James P

Cox, Bryan D; Mehta, Anil K; DiRaddo, John O; Liotta, Dennis C; Wilson, Lawrence J; Snyder, James P.

Afiliación

Cox BD; Emory University, Department of Chemistry, 1515 Dickey Dr., Atlanta, GA 30322, USA.
Mehta AK; Emory University, Department of Chemistry, 1515 Dickey Dr., Atlanta, GA 30322, USA.
DiRaddo JO; Emory University, Department of Chemistry, 1515 Dickey Dr., Atlanta, GA 30322, USA.
Liotta DC; Emory University, Department of Chemistry, 1515 Dickey Dr., Atlanta, GA 30322, USA.
Wilson LJ; Emory University, Department of Chemistry, 1515 Dickey Dr., Atlanta, GA 30322, USA.
Snyder JP; Emory University, Department of Chemistry, 1515 Dickey Dr., Atlanta, GA 30322, USA. Electronic address: jsnyder@emory.edu.

Biochem Biophys Res Commun ; 466(1): 28-32, 2015 Oct 09.

Article en En | MEDLINE | ID: mdl-26301631

Asunto(s)

Receptores CXCR4/antagonistas & inhibidores; Receptores CXCR4/metabolismo; Tetrahidroisoquinolinas/química; Tetrahidroisoquinolinas/farmacología; Animales; Sitios de Unión; Células CHO; Cricetinae; Cricetulus; Humanos; Modelos Moleculares; Resonancia Magnética Nuclear Biomolecular; Unión Proteica; Receptores CXCR4/química

Palabras clave

C-X-C chemokine receptor 4; G-protein-coupled receptors; Ligandreceptor interactions; NMR spectroscopy; Saturation transfer difference

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Receptores CXCR4 / Tetrahidroisoquinolinas Límite: Animals / Humans Idioma: En Revista: Biochem Biophys Res Commun Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos

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