A 5'-upstream short open reading frame encoded peptide regulates angiotensin type 1a receptor production and signalling via the ß-arrestin pathway.
J Physiol
; 594(6): 1601-5, 2016 Mar 15.
Article
en En
| MEDLINE
| ID: mdl-26333095
ABSTRACT
AUG sequences and short open reading frames are commonly present in the 5'-leader sequence of G protein-coupled receptor mRNAs. The presence of these upstream AUG sequences has been demonstrated to inhibit downstream receptor translation efficiency and, most recently, receptor signal transduction. A seven amino acid peptide encoded by a short open reading frame in exon 2 of the angiotensin type 1a receptor has been shown to inhibit non-G protein-coupled signalling of angiotensin II, without altering the classical G protein-coupled pathway activated by the ligand. This finding may lead to the development of a new class of angiotensin receptor antagonists with activities biased for one, but not all, of the signalling cascades activated by angiotensin II, which could have therapeutic implications for the myriad hormones and neurotransmitters that signal through G protein-coupled receptors.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Péptidos
/
Transducción de Señal
/
Sistemas de Lectura Abierta
/
Regiones no Traducidas 5'
/
Receptor de Angiotensina Tipo 1
/
Beta-Arrestinas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Physiol
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos