Your browser doesn't support javascript.
loading
Roles of ROS mediated oxidative stress and DNA damage in 3-methyl-2-quinoxalin benzenevinylketo-1, 4-dioxide-induced immunotoxicity of Sprague-Dawley rats.
Gao, Hui; Wang, Di; Zhang, Shun; Xu, Mengjing; Yang, Wei; Yan, Peipei; Liu, Yang; Luo, Xiao; Wu, Hailei; Yao, Ping; Yan, Hong; Liu, Liegang.
Afiliación
  • Gao H; Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, 13 Hangkong Road, Wuhan, 430030, PR China; MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Scienc
  • Wang D; Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, 13 Hangkong Road, Wuhan, 430030, PR China; MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Scienc
  • Zhang S; MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, 13 Hangkong Road, Wuhan, 430030, PR China.
  • Xu M; Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, 13 Hangkong Road, Wuhan, 430030, PR China; MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Scienc
  • Yang W; Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, 13 Hangkong Road, Wuhan, 430030, PR China; MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Scienc
  • Yan P; Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, 13 Hangkong Road, Wuhan, 430030, PR China; MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Scienc
  • Liu Y; Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, 13 Hangkong Road, Wuhan, 430030, PR China; MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Scienc
  • Luo X; Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, 13 Hangkong Road, Wuhan, 430030, PR China; MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Scienc
  • Wu H; Nanjing Entry-Exit Inspection and Quarantine Bureau, Najing, PR China.
  • Yao P; Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, 13 Hangkong Road, Wuhan, 430030, PR China; MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Scienc
  • Yan H; MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, 13 Hangkong Road, Wuhan, 430030, PR China. Electronic address: yanhong@mails.tjmu.edu.cn.
  • Liu L; Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, 13 Hangkong Road, Wuhan, 430030, PR China; MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Scienc
Regul Toxicol Pharmacol ; 73(2): 587-94, 2015 Nov.
Article en En | MEDLINE | ID: mdl-26361855
3-methyl-2-quinoxalin benzenevinylketo-1, 4-dioxide (Quinocetone, QCT) has been broadly used to treat dysentery and promote animal growth in food producing animals. However, its potential toxicity could not been neglected as parts of safety assessment according to the acceptable guidelines for QCT administration. In this study, the immunotoxicity of QCT was investigated in male Sprague-Dawley (SD) rats following a 28-day oral exposure at doses of 0, 50, 800, and 2400 mg/kg/day. The food consumption, body weight gain and relative spleen weight were significantly decreased by QCT in a dose-dependent manner. Treatment of rats with QCT also notably suppressed the T-cell proliferation and natural killer (NK) cell activity, accompanied by intracellular reactive oxygen species (ROS) accumulation, antioxidant system inhibition and DNA damage enhancement. Thus, the primary finding of this study is that QCT exposure (2400 mg/kg/day) could cause immunotoxicity in SD rats due to ROS mediated oxidative stress and DNA damage.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Quinoxalinas / Daño del ADN / Especies Reactivas de Oxígeno / Estrés Oxidativo Tipo de estudio: Guideline Límite: Animals Idioma: En Revista: Regul Toxicol Pharmacol Año: 2015 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Quinoxalinas / Daño del ADN / Especies Reactivas de Oxígeno / Estrés Oxidativo Tipo de estudio: Guideline Límite: Animals Idioma: En Revista: Regul Toxicol Pharmacol Año: 2015 Tipo del documento: Article