Chlamydia and Gonorrhea in HIV-Infected Pregnant Women and Infant HIV Transmission.
Sex Transm Dis
; 42(10): 554-65, 2015 Oct.
Article
en En
| MEDLINE
| ID: mdl-26372927
ABSTRACT
BACKGROUND:
Sexually transmitted infections (STIs) such as Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) can lead to adverse pregnancy and neonatal outcomes. The prevalence of STIs and its association with HIV mother-to-child transmission (MTCT) were evaluated in a substudy analysis from a randomized, multicenter clinical trial.METHODOLOGY:
Urine samples from HIV-infected pregnant women collected at the time of labor and delivery were tested using polymerase chain reaction testing for the detection of CT and NG (Xpert CT/NG; Cepheid, Sunnyvale, CA). Infant HIV infection was determined by HIV DNA polymerase chain reaction at 3 months.RESULTS:
Of the 1373 urine specimens, 249 (18.1%) were positive for CT and 63 (4.6%) for NG; 35 (2.5%) had both CT and NG detected. Among 117 cases of HIV MTCT (8.5% transmission), the lowest transmission rate occurred among infants born to CT- and NG-uninfected mothers (8.1%) as compared with those infected with only CT (10.7%) and both CT and NG (14.3%; P = 0.04). Infants born to CT-infected mothers had almost a 1.5-fold increased risk for HIV acquisition (odds ratio, 1.47; 95% confidence interval, 0.9-2.3; P = 0.09).CONCLUSIONS:
This cohort of HIV-infected pregnant women is at high risk for infection with CT and NG. Analysis suggests that STIs may predispose to an increased HIV MTCT risk in this high-risk cohort of HIV-infected women.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Complicaciones Infecciosas del Embarazo
/
Infecciones por Chlamydia
/
Gonorrea
/
Seropositividad para VIH
/
Transmisión Vertical de Enfermedad Infecciosa
/
Mujeres Embarazadas
/
Profilaxis Posexposición
/
Madres
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Infant
/
Pregnancy
País/Región como asunto:
Africa
/
America do norte
/
America do sul
/
Argentina
/
Brasil
Idioma:
En
Revista:
Sex Transm Dis
Año:
2015
Tipo del documento:
Article