Genomic alterations in BCL2L1 and DLC1 contribute to drug sensitivity in gastric cancer.

Park, Hansoo; Cho, Sung-Yup; Kim, Hyerim; Na, Deukchae; Han, Jee Yun; Chae, Jeesoo; Park, Changho; Park, Ok-Kyoung; Min, Seoyeon; Kang, Jinjoo; Choi, Boram; Min, Jimin; Kwon, Jee Young; Suh, Yun-Suhk; Kong, Seong-Ho; Lee, Hyuk-Joon; Liu, Edison T; Kim, Jong-Il; Kim, Sunghoon; Yang, Han-Kwang; Lee, Charles

Park, Hansoo; Cho, Sung-Yup; Kim, Hyerim; Na, Deukchae; Han, Jee Yun; Chae, Jeesoo; Park, Changho; Park, Ok-Kyoung; Min, Seoyeon; Kang, Jinjoo; Choi, Boram; Min, Jimin; Kwon, Jee Young; Suh, Yun-Suhk; Kong, Seong-Ho; Lee, Hyuk-Joon; Liu, Edison T; Kim, Jong-Il; Kim, Sunghoon; Yang, Han-Kwang; Lee, Charles.

Afiliación

Park H; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032;
Cho SY; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-799, Korea;
Kim H; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032;
Na D; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-799, Korea;
Han JY; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-799, Korea;
Chae J; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-799, Korea;
Park C; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-799, Korea;
Park OK; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-799, Korea;
Min S; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-799, Korea;
Kang J; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-799, Korea;
Choi B; Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea;
Min J; Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea;
Kwon JY; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032;
Suh YS; Department of Surgery, Seoul National University College of Medicine, Seoul 110-799, Korea;
Kong SH; Department of Surgery, Seoul National University College of Medicine, Seoul 110-799, Korea;
Lee HJ; Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea; Department of Surgery, Seoul National University College of Medicine, Seoul 110-799, Korea;
Liu ET; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032;
Kim JI; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-799, Korea;
Kim S; Medicinal Bioconvergence Research Center, Seoul National University, Seoul 151-742, Korea; Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul 151-742, Korea.
Yang HK; Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea; Department of Surgery, Seoul National University College of Medicine, Seoul 110-799, Korea; Charles.Lee@jax.org hkyang@snu.ac.kr.
Lee C; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-799, Korea; Charles.Lee@jax.org hkyang@snu.ac.kr.

Proc Natl Acad Sci U S A ; 112(40): 12492-7, 2015 Oct 06.

Article en En | MEDLINE | ID: mdl-26401016

Asunto(s)

Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico; Proteínas Activadoras de GTPasa/genética; Estudio de Asociación del Genoma Completo/métodos; Neoplasias Gástricas/tratamiento farmacológico; Neoplasias Gástricas/genética; Proteínas Supresoras de Tumor/genética; Proteína bcl-X/genética; Anciano; Anciano de 80 o más Años; Animales; Línea Celular Tumoral; Supervivencia Celular/genética; Hibridación Genómica Comparativa; Variaciones en el Número de Copia de ADN; Exoma/genética; Femenino; Proteínas Activadoras de GTPasa/metabolismo; Humanos; Subunidad gamma Común de Receptores de Interleucina/deficiencia; Subunidad gamma Común de Receptores de Interleucina/genética; Masculino; Ratones Endogámicos NOD; Ratones Noqueados; Ratones SCID; Persona de Mediana Edad; Mutación; Interferencia de ARN; Análisis de Secuencia de ADN/métodos; Neoplasias Gástricas/patología; Proteínas Supresoras de Tumor/metabolismo; Ensayos Antitumor por Modelo de Xenoinjerto; Proteína bcl-X/metabolismo

Palabras clave

copy number alteration; druggable target; gastric cancer; patient-derived xenograft; whole-exome sequencing

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Protocolos de Quimioterapia Combinada Antineoplásica / Proteínas Activadoras de GTPasa / Proteínas Supresoras de Tumor / Proteína bcl-X / Estudio de Asociación del Genoma Completo Tipo de estudio: Diagnostic_studies Límite: Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2015 Tipo del documento: Article

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