Shedding light on minipig drug metabolism - elevated amide hydrolysis in vitro.

Jones, Russell; Marschmann, Michaela; Keller, Michael; Qiu, Na Hong; Fowler, Stephen; Singer, Thomas; Schuler, Franz; Funk, Christoph; Schadt, Simone

Jones, Russell; Marschmann, Michaela; Keller, Michael; Qiu, Na Hong; Fowler, Stephen; Singer, Thomas; Schuler, Franz; Funk, Christoph; Schadt, Simone.

Afiliación

Jones R; a Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd , Basel , Switzerland and.
Marschmann M; a Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd , Basel , Switzerland and.
Keller M; b Institut fuer Pharmazeutische Wissenschaften, Albert-Ludwigs-Universitaet Freiburg , Freiburg , Germany.
Qiu NH; a Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd , Basel , Switzerland and.
Fowler S; a Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd , Basel , Switzerland and.
Singer T; a Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd , Basel , Switzerland and.
Schuler F; a Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd , Basel , Switzerland and.
Funk C; a Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd , Basel , Switzerland and.
Schadt S; a Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd , Basel , Switzerland and.

Xenobiotica ; 46(6): 483-94, 2016.

Article en En | MEDLINE | ID: mdl-26405846

Asunto(s)

Amidas/metabolismo; Preparaciones Farmacéuticas/metabolismo; Amidas/química; Animales; Western Blotting; Carboxilesterasa/metabolismo; Celecoxib/metabolismo; Hepatocitos/metabolismo; Humanos; Hidrólisis; Hígado/metabolismo; Metaboloma; Microsomas Hepáticos/metabolismo; Especificidad de la Especie; Relación Estructura-Actividad; Fracciones Subcelulares/metabolismo; Porcinos; Porcinos Enanos

Palabras clave

Amide hydrolysis; biotransformation; drug metabolism; esterase; in vitro; metabolite; minipig; species differences

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Preparaciones Farmacéuticas / Amidas Límite: Animals / Humans Idioma: En Revista: Xenobiotica Año: 2016 Tipo del documento: Article

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