Continuous activation of Nrf2 and its target antioxidant enzymes leads to arsenite-induced malignant transformation of human bronchial epithelial cells.

Yang, Xu; Wang, Dapeng; Ma, Yuan; Xu, Xiguo; Zhu, Zhen; Wang, Xiaojuan; Deng, Hanyi; Li, Chunchun; Chen, Min; Tong, Jian; Yamanaka, Kenzo; An, Yan

Yang, Xu; Wang, Dapeng; Ma, Yuan; Xu, Xiguo; Zhu, Zhen; Wang, Xiaojuan; Deng, Hanyi; Li, Chunchun; Chen, Min; Tong, Jian; Yamanaka, Kenzo; An, Yan.

Afiliación

Yang X; Department of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Wang D; Department of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China; Department of Toxicology, School of Public Health, Guizhou Medical University
Ma Y; Department of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Xu X; Department of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Zhu Z; Department of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Wang X; Department of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Deng H; Department of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Li C; Department of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Chen M; Department of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Tong J; Department of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China.
Yamanaka K; Laboratory of Environmental Toxicology and Carcinogenesis, School of Pharmacy, Nihon University, Chiba, Japan.
An Y; Department of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu, People's Republic of China. Electronic address: dranyan@126.com.

Toxicol Appl Pharmacol ; 289(2): 231-9, 2015 Dec 01.

Article en En | MEDLINE | ID: mdl-26420645

Asunto(s)

Antioxidantes/metabolismo; Arsenitos/toxicidad; Bronquios/efectos de los fármacos; Carcinógenos/toxicidad; Transformación Celular Neoplásica/inducido químicamente; Células Epiteliales/efectos de los fármacos; Neoplasias Pulmonares/inducido químicamente; Factor 2 Relacionado con NF-E2/agonistas; Compuestos de Sodio/toxicidad; Bronquios/enzimología; Bronquios/patología; Línea Celular; Movimiento Celular/efectos de los fármacos; Proliferación Celular/efectos de los fármacos; Transformación Celular Neoplásica/genética; Transformación Celular Neoplásica/metabolismo; Transformación Celular Neoplásica/patología; Activación Enzimática; Células Epiteliales/enzimología; Células Epiteliales/patología; Hemo-Oxigenasa 1/metabolismo; Humanos; Péptidos y Proteínas de Señalización Intracelular/metabolismo; Proteína 1 Asociada A ECH Tipo Kelch; Neoplasias Pulmonares/enzimología; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/patología; Malondialdehído/metabolismo; NAD(P)H Deshidrogenasa (Quinona)/metabolismo; Factor 2 Relacionado con NF-E2/genética; Factor 2 Relacionado con NF-E2/metabolismo; Invasividad Neoplásica; Estrés Oxidativo/efectos de los fármacos; Fenotipo; Interferencia de ARN; Especies Reactivas de Oxígeno/metabolismo; Transducción de Señal/efectos de los fármacos; Superóxido Dismutasa/metabolismo; Factores de Tiempo; Transfección

Palabras clave

Antioxidant response; Arsenite; Carcinogenesis; HBE cells; Nrf2

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Bronquios / Carcinógenos / Transformación Celular Neoplásica / Compuestos de Sodio / Arsenitos / Células Epiteliales / Factor 2 Relacionado con NF-E2 / Neoplasias Pulmonares / Antioxidantes Idioma: En Revista: Toxicol Appl Pharmacol Año: 2015 Tipo del documento: Article

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