Site-Directed Mutagenesis of Surface-Exposed Lysine Residues Leads to Improved Transduction by AAV2, But Not AAV8, Vectors in Murine Hepatocytes In Vivo.

Li, Baozheng; Ma, Wenqin; Ling, Chen; Van Vliet, Kim; Huang, Lin-Ya; Agbandje-McKenna, Mavis; Srivastava, Arun; Aslanidi, George V

Li, Baozheng; Ma, Wenqin; Ling, Chen; Van Vliet, Kim; Huang, Lin-Ya; Agbandje-McKenna, Mavis; Srivastava, Arun; Aslanidi, George V.

Afiliación

Li B; 1 Division of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida College of Medicine , Gainesville, Florida.
Ma W; 1 Division of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida College of Medicine , Gainesville, Florida.
Ling C; 1 Division of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida College of Medicine , Gainesville, Florida.
Van Vliet K; 2 Powell Gene Therapy Center, University of Florida College of Medicine , Gainesville, Florida.
Huang LY; 3 Genetics Institute, University of Florida College of Medicine , Gainesville, Florida.
Agbandje-McKenna M; 4 Department of Biochemistry and Molecular Biology, University of Florida College of Medicine , Gainesville, Florida.
Srivastava A; 4 Department of Biochemistry and Molecular Biology, University of Florida College of Medicine , Gainesville, Florida.
Aslanidi GV; 2 Powell Gene Therapy Center, University of Florida College of Medicine , Gainesville, Florida.

Hum Gene Ther Methods ; 26(6): 211-20, 2015 Dec.

Article en En | MEDLINE | ID: mdl-26421998

Asunto(s)

Proteínas de la Cápside/genética; Dependovirus/clasificación; Dependovirus/genética; Vectores Genéticos/genética; Hepatocitos/metabolismo; Lisina; Mutagénesis Sitio-Dirigida; Transducción Genética; Animales; Proteínas de la Cápside/química; Línea Celular; Células Cultivadas; Expresión Génica; Genes Reporteros; Humanos; Ratones; Transgenes

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Transducción Genética / Mutagénesis Sitio-Dirigida / Dependovirus / Hepatocitos / Proteínas de la Cápside / Vectores Genéticos / Lisina Límite: Animals / Humans Idioma: En Revista: Hum Gene Ther Methods Año: 2015 Tipo del documento: Article

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