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MicroRNAs in placental health and disease.
Mouillet, Jean-François; Ouyang, Yingshi; Coyne, Carolyn B; Sadovsky, Yoel.
Afiliación
  • Mouillet JF; Magee-Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA.
  • Ouyang Y; Magee-Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA.
  • Coyne CB; Magee-Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA.
  • Sadovsky Y; Magee-Womens Research Institute, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA. Electronic address: ysadovsky@mwri.magee.edu.
Am J Obstet Gynecol ; 213(4 Suppl): S163-72, 2015 Oct.
Article en En | MEDLINE | ID: mdl-26428496
MicroRNAs (miRNAs) constitute a large family of small noncoding RNAs that are encoded by the genomes of most organisms. They regulate gene expression through posttranscriptional mechanisms to attenuate protein output in various genetic networks. The discovery of miRNAs has transformed our understanding of gene regulation and sparked intense efforts intended to harness their potential as diagnostic markers and therapeutic tools. Over the last decade, a flurry of studies has shed light on placental miRNAs but has also raised many questions regarding the scope of their biologic action. Moreover, the recognition that miRNAs of placental origin are released continually in the maternal circulation throughout pregnancy suggested that circulating miRNAs might serve as biomarkers for placental function during pregnancy. Although this generated much enthusiasm, recently recognized challenges have delayed the application of miRNA-based biomarkers and therapeutics in clinical practice. In this review, we summarize key findings in the field and discuss current knowledge related to miRNAs in the context of placental biology.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedades Placentarias / MicroARNs Límite: Female / Humans / Pregnancy Idioma: En Revista: Am J Obstet Gynecol Año: 2015 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedades Placentarias / MicroARNs Límite: Female / Humans / Pregnancy Idioma: En Revista: Am J Obstet Gynecol Año: 2015 Tipo del documento: Article