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Enhancing our understanding of enhancers in T-helper cells.
Paiano, Jacob J; Johnson, John L; Vahedi, Golnaz.
Afiliación
  • Paiano JJ; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Johnson JL; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Vahedi G; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Eur J Immunol ; 45(11): 2998-3001, 2015 Nov.
Article en En | MEDLINE | ID: mdl-26444855
A long-standing question in immunology has been to understand how transcription factors (TF) determine cell-type-specific transcription programs. Traditionally, investigating TFs in immune cells has been limited to measuring the effect of a single TF on a limited number of gene targets. The advent of next generation sequencing methods makes it possible to measure the effects of multiple transcription factors on a genome-wide scale. This holistic approach gives us a better understanding of the influence that multiple TFs have on cell-specific programs. In this issue of European Journal of Immunology, Fang et al. [Eur. J. Immunol. 2015. 45: 3150-3157] show that genomic regions cooccupied with two or more TFs show increased epigenetic histone marks of active enhancers, which correspond to increased transcriptional activity.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Regulación de la Expresión Génica / Subgrupos de Linfocitos T / Linfocitos T Colaboradores-Inductores Límite: Animals Idioma: En Revista: Eur J Immunol Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Regulación de la Expresión Génica / Subgrupos de Linfocitos T / Linfocitos T Colaboradores-Inductores Límite: Animals Idioma: En Revista: Eur J Immunol Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos