Propofol effects on cerebellar long-term depression.
Neurosci Lett
; 609: 18-22, 2015 Nov 16.
Article
en En
| MEDLINE
| ID: mdl-26455962
ABSTRACT
Propofol is an intravenously administered anesthetic that induces γ-aminobutyric acid-mediated inhibition in the central nervous system. It has been implicated in prolonged movement disorders. Since the cerebellum is important for motor coordination and learning, we investigated the potential effects of propofol on cerebellar circuitry. Using the whole-cell patch-clamp technique in Wister rat cerebellar slices, we demonstrated that propofol administration impaired long-term depression from the parallel fiber (PF) to Purkinje cell (PC) synapses (PF-LTD). Also, propofol reduced metabotropic glutamate receptor 1 (mGluR1)-mediated and group I mGluR agonist-induced slow currents in PCs. These results suggest that the propofol-induced PF-LTD impairment may be related to an alteration in mGluR1 signaling, which is essential to motor learning.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Propofol
/
Cerebelo
/
Anestésicos Intravenosos
/
Depresión Sináptica a Largo Plazo
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
2015
Tipo del documento:
Article