Over-expression of prothymosin-&#945; antagonizes TGFß signalling to promote the development of emphysema.

Su, Bing-Hua; Tseng, Yau-Lin; Shieh, Gia-Shing; Chen, Yi-Cheng; Wu, Pensee; Shiau, Ai-Li; Wu, Chao-Liang

Over-expression of prothymosin-α antagonizes TGFß signalling to promote the development of emphysema.

Su, Bing-Hua; Tseng, Yau-Lin; Shieh, Gia-Shing; Chen, Yi-Cheng; Wu, Pensee; Shiau, Ai-Li; Wu, Chao-Liang.

Afiliación

Su BH; Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Tseng YL; Division of Thoracic Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Shieh GS; Department of Urology, Tainan Hospital, Ministry of Health and Welfare, Tainan, Taiwan.
Chen YC; Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Wu P; Institute for Science and Technology in Medicine, Keele University, UK.
Shiau AL; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Wu CL; Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

J Pathol ; 238(3): 412-22, 2016 Feb.

Article en En | MEDLINE | ID: mdl-26496995

Asunto(s)

Precursores de Proteínas/metabolismo; Enfisema Pulmonar/etiología; Timosina/análogos & derivados; Factor de Crecimiento Transformador beta/antagonistas & inhibidores; Acetilación; Animales; Estudios de Casos y Controles; Células Cultivadas; Modelos Animales de Enfermedad; Regulación hacia Abajo/fisiología; Histona Desacetilasas/metabolismo; Humanos; Masculino; Metaloproteinasas de la Matriz/metabolismo; Ratones; Ratones Transgénicos; Transducción de Señal/fisiología; Proteína smad7/metabolismo; Timosina/metabolismo; Inhibidor Tisular de Metaloproteinasa-3/genética; Inhibidor Tisular de Metaloproteinasa-3/metabolismo; Transcripción Genética/genética

Palabras clave

COPD; HDAC; Smad7; TGFß; TIMP-3; emphysema; prothymosin α

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Precursores de Proteínas / Enfisema Pulmonar / Timosina / Factor de Crecimiento Transformador beta Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Animals / Humans / Male Idioma: En Revista: J Pathol Año: 2016 Tipo del documento: Article País de afiliación: Taiwán

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