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Allosteric activation of M4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice.
Pancani, Tristano; Foster, Daniel J; Moehle, Mark S; Bichell, Terry Jo; Bradley, Emma; Bridges, Thomas M; Klar, Rebecca; Poslusney, Mike; Rook, Jerri M; Daniels, J Scott; Niswender, Colleen M; Jones, Carrie K; Wood, Michael R; Bowman, Aaron B; Lindsley, Craig W; Xiang, Zixiu; Conn, P Jeffrey.
Afiliación
  • Pancani T; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232;
  • Foster DJ; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232;
  • Moehle MS; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232;
  • Bichell TJ; Department of Neurology, Vanderbilt University, Nashville, TN 37232;
  • Bradley E; Department of Neurology, Vanderbilt University, Nashville, TN 37232;
  • Bridges TM; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232;
  • Klar R; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232;
  • Poslusney M; Lieber Institute for Brain Development, Baltimore, MD 21205.
  • Rook JM; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232;
  • Daniels JS; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232;
  • Niswender CM; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232;
  • Jones CK; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232;
  • Wood MR; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232;
  • Bowman AB; Department of Neurology, Vanderbilt University, Nashville, TN 37232;
  • Lindsley CW; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232;
  • Xiang Z; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232; zixiu.xiang@vanderbilt.edu jeff.conn@vanderbilt.edu.
  • Conn PJ; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232; zixiu.xiang@vanderbilt.edu jeff.conn@vanderbilt.edu.
Proc Natl Acad Sci U S A ; 112(45): 14078-83, 2015 Nov 10.
Article en En | MEDLINE | ID: mdl-26508634
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de Huntington / Transmisión Sináptica / Ácido Glutámico / Receptor Muscarínico M4 / Regulación Alostérica Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2015 Tipo del documento: Article
Texto completo
Imprimir
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PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedad de Huntington / Transmisión Sináptica / Ácido Glutámico / Receptor Muscarínico M4 / Regulación Alostérica Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2015 Tipo del documento: Article