The murine cytomegalovirus immunoevasin gp40 binds MHC class I molecules to retain them in the early secretory pathway.
J Cell Sci
; 129(1): 219-27, 2016 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-26527401
ABSTRACT
In the presence of the murine cytomegalovirus (mCMV) gp40 (m152) protein, murine major histocompatibility complex (MHC) class I molecules do not reach the cell surface but are retained in an early compartment of the secretory pathway. We find that gp40 does not impair the folding or high-affinity peptide binding of the class I molecules but binds to them, leading to their retention in the endoplasmic reticulum (ER), the ER-Golgi intermediate compartment (ERGIC) and the cis-Golgi, most likely by retrieval from the cis-Golgi to the ER. We identify a sequence in gp40 that is required for both its own retention in the early secretory pathway and for that of class I molecules.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas Virales
/
Antígenos de Histocompatibilidad Clase I
/
Muromegalovirus
/
Vías Secretoras
Límite:
Animals
Idioma:
En
Revista:
J Cell Sci
Año:
2016
Tipo del documento:
Article
País de afiliación:
Alemania