Meroterpenoids from a Tropical Dysidea sp. Sponge.
J Nat Prod
; 78(11): 2814-21, 2015 Nov 25.
Article
en En
| MEDLINE
| ID: mdl-26551342
ABSTRACT
Six new meroterpenoids (1-6), along with arenarol (7), a known rearranged drimane sesquiterpene hydroquinone, were isolated from a Dysidea sp. sponge collected from the Federated States of Micronesia. On the basis of the results of combined spectroscopic analysis, compound 1 was determined to be the cyclic ether derivative of 7, whereas 2 and 3 were assigned as the corresponding sesquiterpene quinones containing taurine-derived substituents. Compounds 4-6 possess a novel tetracyclic skeleton formed by a direct linkage between the quinone and sesquiterpene moieties. The configurations of these new compounds were assigned on the basis of combined NOESY and ECD analysis. These compounds exhibited cytotoxic and antimicrobial activities and weak inhibition against Na(+)/K(+)-ATPase.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sesquiterpenos
/
Terpenos
/
Citotoxinas
/
Dysidea
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Nat Prod
Año:
2015
Tipo del documento:
Article