Application of Micropatterned Cocultured Hepatocytes to Evaluate the Inductive Potential and Degradation Rate of Major Xenobiotic Metabolizing Enzymes.

Dixit, Vaishali; Moore, Amanda; Tsao, Hong; Hariparsad, Niresh

Dixit, Vaishali; Moore, Amanda; Tsao, Hong; Hariparsad, Niresh.

Afiliación

Dixit V; Drug Metabolism and Pharmacokinetics, Vertex Pharmaceuticals Incorporated, Boston, Massachusetts niresh_hariparsad@vrtx.com.
Moore A; Drug Metabolism and Pharmacokinetics, Vertex Pharmaceuticals Incorporated, Boston, Massachusetts.
Tsao H; Drug Metabolism and Pharmacokinetics, Vertex Pharmaceuticals Incorporated, Boston, Massachusetts.
Hariparsad N; Drug Metabolism and Pharmacokinetics, Vertex Pharmaceuticals Incorporated, Boston, Massachusetts.

Drug Metab Dispos ; 44(2): 250-61, 2016 Feb.

Article en En | MEDLINE | ID: mdl-26658225

Asunto(s)

Sistema Enzimático del Citocromo P-450/metabolismo; Hepatocitos/metabolismo; Xenobióticos/metabolismo; Transporte Biológico/fisiología; Células Cultivadas; Técnicas de Cocultivo/métodos; Semivida; Humanos; Fenobarbital/metabolismo; Fenitoína/metabolismo; ARN Mensajero/metabolismo; Rifampin/metabolismo

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Xenobióticos / Hepatocitos / Sistema Enzimático del Citocromo P-450 Límite: Humans Idioma: En Revista: Drug Metab Dispos Asunto de la revista: FARMACOLOGIA Año: 2016 Tipo del documento: Article

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