Tanshinone IIA ameliorates dextran sulfate sodium-induced inflammatory bowel disease via the pregnane X receptor.

Zhang, Xianxie; Wang, Yuguang; Ma, Zengchun; Liang, Qiande; Tang, Xianglin; Hu, Donghua; Tan, Hongling; Xiao, Chengrong; Gao, Yue

Zhang, Xianxie; Wang, Yuguang; Ma, Zengchun; Liang, Qiande; Tang, Xianglin; Hu, Donghua; Tan, Hongling; Xiao, Chengrong; Gao, Yue.

Afiliación

Zhang X; Air Force General Hospital of People's Liberation Army, Beijing, People's Republic of China.
Wang Y; Department of Pharmacology and Toxicology, Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
Ma Z; Department of Pharmacology and Toxicology, Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
Liang Q; Department of Pharmacology and Toxicology, Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
Tang X; Department of Pharmacology and Toxicology, Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
Hu D; Department of Pharmacology and Toxicology, Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
Tan H; Department of Pharmacology and Toxicology, Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
Xiao C; Department of Pharmacology and Toxicology, Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
Gao Y; Department of Pharmacology and Toxicology, Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.

Drug Des Devel Ther ; 9: 6343-62, 2015.

Article en En | MEDLINE | ID: mdl-26674743

Asunto(s)

Abietanos/farmacología; Sulfato de Dextran/antagonistas & inhibidores; Enfermedades Inflamatorias del Intestino/inducido químicamente; Enfermedades Inflamatorias del Intestino/tratamiento farmacológico; Receptores de Esteroides/agonistas; Animales; Colitis/inducido químicamente; Colitis/tratamiento farmacológico; Citocromo P-450 CYP3A/genética; Citocromo P-450 CYP3A/metabolismo; Relación Dosis-Respuesta a Droga; Células Hep G2; Humanos; Masculino; Ratones; Ratones Endogámicos BALB C; Receptor X de Pregnano; ARN Mensajero/genética; Receptores de Esteroides/metabolismo; Relación Estructura-Actividad; Células Tumorales Cultivadas

Palabras clave

Crohn's disease; dashen; dextran sodium sulfate; inflammatory bowel disease; pregnane X receptor; tanshinone IIA; ulcerative colitis

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedades Inflamatorias del Intestino / Receptores de Esteroides / Sulfato de Dextran / Abietanos Límite: Animals / Humans / Male Idioma: En Revista: Drug Des Devel Ther Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2015 Tipo del documento: Article

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