A new family of water-soluble, third generation antitumor platinum complexes.
J Med Chem
; 32(9): 2063-7, 1989 Sep.
Article
en En
| MEDLINE
| ID: mdl-2671371
ABSTRACT
[1,1-Cyclobutanedicarboxylato(2)-O,O'](1,3-dioxane-5,5-dimethan amine- N,N')platinum(II), 3a, a third generation, very water-soluble platinum complex, has been synthesized along with several of its analogues. All members of the new family contain a 1,3-dioxane or 1,3-dioxolane-1,3-diamine as their basic ligand, a moiety which contributes to their increased water solubility, and a bidentate acid ligand, which is responsible for their good stability. They were all easily crystallized and characterized by 1H NMR and elemental analysis, and the parent complex 3a was further characterized by 13C NMR. Their very desirable physical properties combined with their broad spectrum of antitumor activity and reduced toxicity make them good candidates of further development.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Compuestos Organoplatinos
/
Dioxanos
/
Dioxinas
/
Dioxolanos
/
Dioxoles
/
Antineoplásicos
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
J Med Chem
Asunto de la revista:
QUIMICA
Año:
1989
Tipo del documento:
Article