Meiotic DSB patterning: A multifaceted process.
Cell Cycle
; 15(1): 13-21, 2016.
Article
en En
| MEDLINE
| ID: mdl-26730703
ABSTRACT
Meiosis is a specialized two-step cell division responsible for genome haploidization and the generation of genetic diversity during gametogenesis. An integral and distinctive feature of the meiotic program is the evolutionarily conserved initiation of homologous recombination (HR) by the developmentally programmed induction of DNA double-strand breaks (DSBs). The inherently dangerous but essential act of DSB formation is subject to multiple forms of stringent and self-corrective regulation that collectively ensure fruitful and appropriate levels of genetic exchange without risk to cellular survival. Within this article we focus upon an emerging element of this control--spatial regulation--detailing recent advances made in understanding how DSBs are evenly distributed across the genome, and present a unified view of the underlying patterning mechanisms employed.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Reparación del ADN
/
Roturas del ADN de Doble Cadena
/
Meiosis
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cell Cycle
Año:
2016
Tipo del documento:
Article
País de afiliación:
Reino Unido