Formins at the Junction.
Trends Biochem Sci
; 41(2): 148-159, 2016 Feb.
Article
en En
| MEDLINE
| ID: mdl-26732401
ABSTRACT
The actin cytoskeleton and adhesion junctions are physically and functionally coupled at the cell-cell interface between epithelial cells. The actin regulatory complex Arp2/3 has an established role in the turnover of junctional actin; however, the role of formins, the largest group of actin regulators, is less clear. Formins dynamically shape the actin cytoskeleton and have various functions within cells. In this review we describe recent progress on how formins regulate actin dynamics at cell-cell contacts and highlight formin functions during polarized protein traffic necessary for epithelialization.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Citoesqueleto de Actina
/
Uniones Adherentes
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Biochem Sci
Año:
2016
Tipo del documento:
Article