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Incomplete Hippocampal Inversion: A Comprehensive MRI Study of Over 2000 Subjects.
Cury, Claire; Toro, Roberto; Cohen, Fanny; Fischer, Clara; Mhaya, Amel; Samper-González, Jorge; Hasboun, Dominique; Mangin, Jean-François; Banaschewski, Tobias; Bokde, Arun L W; Bromberg, Uli; Buechel, Christian; Cattrell, Anna; Conrod, Patricia; Flor, Herta; Gallinat, Juergen; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Lemaitre, Hervé; Martinot, Jean-Luc; Nees, Frauke; Paillère Martinot, Marie-Laure; Orfanos, Dimitri P; Paus, Tomas; Poustka, Luise; Smolka, Michael N; Walter, Henrik; Whelan, Robert; Frouin, Vincent; Schumann, Gunter; Glaunès, Joan A; Colliot, Olivier.
Afiliación
  • Cury C; Institut national de la santé et de la recherche médicale, U1127Paris, France; Centre National de la Recherche Scientifique, UMR 7225 Institut du Cerveau et de la Moelle épinièreParis, France; Sorbonne Universités, Université Pierre et Marie Curie Univ Paris 06, UMR S 1127Paris, France; Institut du
  • Toro R; Centre National de la Recherche Scientifique, Genes, Synapses and Cognition, URA 2182, Institut PasteurParis, France; Human Genetics and Cognitive Functions, Institut PasteurParis, France.
  • Cohen F; Institut national de la santé et de la recherche médicale, U1127Paris, France; Centre National de la Recherche Scientifique, UMR 7225 Institut du Cerveau et de la Moelle épinièreParis, France; Sorbonne Universités, Université Pierre et Marie Curie Univ Paris 06, UMR S 1127Paris, France; Institut du
  • Fischer C; Centre d'Acquisition et de Traitement des ImagesParis, France; Institut d'Imagerie Biomédicale; Commissariat à l'énergie atomique et aux énergies alternatives; Direction des Sciences du VivantGif-Sur-Yvette, France.
  • Mhaya A; Institut national de la santé et de la recherche médicale, U1127Paris, France; Centre National de la Recherche Scientifique, UMR 7225 Institut du Cerveau et de la Moelle épinièreParis, France; Sorbonne Universités, Université Pierre et Marie Curie Univ Paris 06, UMR S 1127Paris, France; Institut du
  • Samper-González J; Institut national de la santé et de la recherche médicale, U1127Paris, France; Centre National de la Recherche Scientifique, UMR 7225 Institut du Cerveau et de la Moelle épinièreParis, France; Sorbonne Universités, Université Pierre et Marie Curie Univ Paris 06, UMR S 1127Paris, France; Institut du
  • Hasboun D; Institut national de la santé et de la recherche médicale, U1127Paris, France; Centre National de la Recherche Scientifique, UMR 7225 Institut du Cerveau et de la Moelle épinièreParis, France; Sorbonne Universités, Université Pierre et Marie Curie Univ Paris 06, UMR S 1127Paris, France; Institut du
  • Mangin JF; Centre d'Acquisition et de Traitement des ImagesParis, France; Institut d'Imagerie Biomédicale; Commissariat à l'énergie atomique et aux énergies alternatives; Direction des Sciences du VivantGif-Sur-Yvette, France.
  • Banaschewski T; Department of Child and Adolescent Psychiatry and Psychotherapy, Clinical Faculty Mannheim, Central Institute of Mental Health, University of Heidelberg Mannheim, Germany.
  • Bokde AL; Discipline of Psychiatry, School of Medicine, Trinity College DublinDublin, Ireland; Institute of Neuroscience, Trinity College DublinDublin, Ireland.
  • Bromberg U; Department of Systems Neuroscience, Universitätsklinikum Hamburg Eppendorf Hamburg, Germany.
  • Buechel C; Department of Systems Neuroscience, Universitätsklinikum Hamburg EppendorfHamburg, Germany; Department of Psychology, Stanford UniversityStanford, CA, USA.
  • Cattrell A; Institute of Psychiatry, Psychology and Neuroscience, King's College LondonLondon, UK; MRC Social, Genetic and Developmental Psychiatry CentreLondon, UK.
  • Conrod P; Institute of Psychiatry, Psychology and Neuroscience, King's College LondonLondon, UK; Département de Psychiatrie, Centre Hospitalier Universitaire Sainte-Justine, Université de MontrealMontreal, QC, Canada.
  • Flor H; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University Mannheim, Germany.
  • Gallinat J; Department of Systems Neuroscience, Universitätsklinikum Hamburg EppendorfHamburg, Germany; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin BerlinGermany.
  • Garavan H; Discipline of Psychiatry, School of Medicine, Trinity College Dublin Dublin, Ireland.
  • Gowland P; School of Physics and Astronomy, University of Nottingham Nottingham, UK.
  • Heinz A; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin Berlin Germany.
  • Ittermann B; Physikalisch-Technische Bundesanstalt Berlin, Germany.
  • Lemaitre H; Institut national de la santé et de la recherche médicale U1000, Neuroimagerie en Psychiatrie, Université Paris-Sud, Université Paris Descartes Paris, France.
  • Martinot JL; Institut national de la santé et de la recherche médicale U1000, Neuroimagerie en Psychiatrie, Université Paris-Sud, Université Paris Descartes Paris, France.
  • Nees F; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University Mannheim, Germany.
  • Paillère Martinot ML; Institut national de la santé et de la recherche médicale U1000, Neuroimagerie en Psychiatrie, Université Paris-Sud, Université Paris DescartesParis, France; AP-HP, Department of Adolescent Psychopathology and Medicine, Maison de Solenn, Cochin Hospital, University Paris Descartes, Sorbonne Paris Ci
  • Orfanos DP; Institut d'Imagerie Biomédicale; Commissariat à l'énergie atomique et aux énergies alternatives; Direction des Sciences du Vivant Gif-Sur-Yvette, France.
  • Paus T; Rotman Research Institute, BaycrestToronto, ON, Canada; Departments of Psychology and Psychiatry, University of TorontoToronto, Canada; Center for Developing Brain, Child Mind InstituteNew York, NY, USA.
  • Poustka L; Department of Child and Adolescent Psychiatry and Psychotherapy, Clinical Faculty Mannheim, Central Institute of Mental Health, University of HeidelbergMannheim, Germany; Department of Child and Adolescent Psychiatry, Medical University of ViennaVienna, Austria.
  • Smolka MN; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden Dresden, Germany.
  • Walter H; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin BerlinGermany; Berlin School of Mind and Brain, Humboldt University BerlinBerlin, Germany.
  • Whelan R; Department of Psychology, University College Dublin Dublin, Ireland.
  • Frouin V; Institut d'Imagerie Biomédicale; Commissariat à l'énergie atomique et aux énergies alternatives; Direction des Sciences du Vivant Gif-Sur-Yvette, France.
  • Schumann G; Institute of Psychiatry, Psychology and Neuroscience, King's College LondonLondon, UK; MRC Social, Genetic and Developmental Psychiatry CentreLondon, UK.
  • Glaunès JA; MAP5, Université Paris Descartes, Sorbonne Paris Cité Paris, France.
  • Colliot O; Institut national de la santé et de la recherche médicale, U1127Paris, France; Centre National de la Recherche Scientifique, UMR 7225 Institut du Cerveau et de la Moelle épinièreParis, France; Sorbonne Universités, Université Pierre et Marie Curie Univ Paris 06, UMR S 1127Paris, France; Institut du
Front Neuroanat ; 9: 160, 2015.
Article en En | MEDLINE | ID: mdl-26733822
ABSTRACT
The incomplete-hippocampal-inversion (IHI), also known as malrotation, is an atypical anatomical pattern of the hippocampus, which has been reported in healthy subjects in different studies. However, extensive characterization of IHI in a large sample has not yet been performed. Furthermore, it is unclear whether IHI are restricted to the medial-temporal lobe or are associated with more extensive anatomical changes. Here, we studied the characteristics of IHI in a community-based sample of 2008 subjects of the IMAGEN database and their association with extra-hippocampal anatomical variations. The presence of IHI was assessed on T1-weighted anatomical magnetic resonance imaging (MRI) using visual criteria. We assessed the association of IHI with other anatomical changes throughout the brain using automatic morphometry of cortical sulci. We found that IHI were much more frequent in the left hippocampus (left 17%, right 6%, χ(2)-test, p < 10(-28)). Compared to subjects without IHI, subjects with IHI displayed morphological changes in several sulci located mainly in the limbic lobe. Our results demonstrate that IHI are a common left-sided phenomenon in normal subjects and that they are associated with morphological changes outside the medial temporal lobe.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Front Neuroanat Año: 2015 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Front Neuroanat Año: 2015 Tipo del documento: Article