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Di(ethylene glycol) methyl ether methacrylate (DEGMEMA)-derived gels align small organic molecules in methanol.
García, Manuela E; Woodruff, Shannon R; Hellemann, Erich; Tsarevsky, Nicolay V; Gil, Roberto R.
Afiliación
  • García ME; Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA, 15213, USA.
  • Woodruff SR; Department of Organic Chemistry, National University of Cordoba, Medina Allende y Haya de La Torre, Cordoba, 5000, Argentina.
  • Hellemann E; Department of Chemistry, Southern Methodist University, Dallas, TX, USA.
  • Tsarevsky NV; Center for Drug Discovery, Design, and Delivery in Dedman College, Southern Methodist University, Dallas, TX, USA.
  • Gil RR; Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA, 15213, USA.
Magn Reson Chem ; 55(3): 206-209, 2017 Mar.
Article en En | MEDLINE | ID: mdl-26763068
Residual dipolar couplings (RDCs) constitute an important NMR parameter for structural elucidation in all areas of chemistry. In this study, di(ethylene glycol) methyl ether methacrylate (DEGMEMA)-based gels are introduced as alignment media for the measurement of RDCs of small organic molecules in polar solvents such as methanol. The low viscosity of methanol permits the execution of J-scaled BIRD HSQC experiments that yield very sharp lines in anisotropic conditions. The gels have excellent mechanical properties, and their compression and expansion in the swollen state can be reversed and performed multiple times. This process enables the easy loading and release of analytes. The excellent performance of these new aligning gels is demonstrated by analyzing the structure of the alkaloid retrorsine. Copyright © 2016 John Wiley & Sons, Ltd.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Alcaloides de Pirrolicidina / Glicoles de Etileno / Metacrilatos Idioma: En Revista: Magn Reson Chem Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Alcaloides de Pirrolicidina / Glicoles de Etileno / Metacrilatos Idioma: En Revista: Magn Reson Chem Asunto de la revista: QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos