MuCor: mutation aggregation and correlation.
Bioinformatics
; 32(10): 1557-8, 2016 05 15.
Article
en En
| MEDLINE
| ID: mdl-26803155
ABSTRACT
MOTIVATION There are many tools for variant calling and effect prediction, but little to tie together large sample groups. Aggregating, sorting and summarizing variants and effects across a cohort is often done with ad hoc scripts that must be re-written for every new project. In response, we have written MuCor, a tool to gather variants from a variety of input formats (including multiple files per sample), perform database lookups and frequency calculations, and write many types of reports. In addition to use in large studies with numerous samples, MuCor can also be employed to directly compare variant calls from the same sample across two or more platforms, parameters or pipelines. A companion utility, DepthGauge, measures coverage at regions of interest to increase confidence in calls. AVAILABILITY AND IMPLEMENTATION Source code is freely available at https//github.com/blachlylab/mucor and a Docker image is available at https//hub.docker.com/r/blachlylab/mucor/ CONTACT james.blachly@osumc.eduSupplementary data Supplementary data are available at Bioinformatics online.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Programas Informáticos
/
Mutación
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Bioinformatics
Asunto de la revista:
INFORMATICA MEDICA
Año:
2016
Tipo del documento:
Article