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Rh(III)-Catalyzed Redox-Neutral Annulation of Primary Benzamides with Diazo Compounds: Approach to Isoquinolinones.
Wu, Youzhi; Sun, Peng; Zhang, Kaifan; Yang, Tie; Yao, Hequan; Lin, Aijun.
Afiliación
  • Wu Y; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University , Nanjing, 210009, P. R. China.
  • Sun P; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University , Nanjing, 210009, P. R. China.
  • Zhang K; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University , Nanjing, 210009, P. R. China.
  • Yang T; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University , Nanjing, 210009, P. R. China.
  • Yao H; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University , Nanjing, 210009, P. R. China.
  • Lin A; State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University , Nanjing, 210009, P. R. China.
J Org Chem ; 81(5): 2166-73, 2016 Mar 04.
Article en En | MEDLINE | ID: mdl-26821090
ABSTRACT
Reported herein is a Rh-catalyzed redox-neutral annulation of primary benzamides with diazo compounds, representing an efficient and economic protocol to isoquinolinones. The procedure exhibited good functional group tolerability, scalability, and regioselectivity, obviating the need for oxidants, and only environmentally benign N2 and H2O were released. Further utilization of the method provided an alternative route to functionalized isoquinolines.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2016 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2016 Tipo del documento: Article