Enhancement of functional MRI signal at high-susceptibility regions of brain using simultaneous multiecho multithin-slice summation imaging technique.
J Magn Reson Imaging
; 44(2): 478-85, 2016 08.
Article
en En
| MEDLINE
| ID: mdl-26821385
ABSTRACT
PURPOSE:
To increase temporal-signal-to-noise ratio (tSNR) and blood oxygen level-dependent (BOLD) sensitivity at high-susceptibility regions of the brain by means of a simultaneous multiecho multithin-slice summation imaging technique. MATERIALS ANDMETHODS:
The simultaneous multislice (SMS) technique was implemented with multiecho (SMSME) and multiecho with thin-slice summation (SMSME-thin) at 3T. Multiecho data were summated based on the local apparent T2* weighting factor. Ten healthy subjects were studied for the whole brain activation by breath-holding. The tSNR values and the number of activated pixels acquired with SMSME and SMSME-thin were compared with those acquired with the conventional gradient-echo EPI in multiple brain regionsRESULTS:
SMS methods accelerated imaging time by 5-fold as compared with the conventional method, resulting in the acquisition of three echoes and four thin-slices during the same TR of 2.5 seconds. At high-susceptibility regions, including the amygdala, inferior and middle temporal, and anterior frontal lobes, SMSME increased tSNR values by up to â¼80% and BOLD activation by up to â¼20% (paired t-test, P < 0.05). SMSME-thin further increased values as compared with SMSME (â¼45% for tSNR and â¼20% for activation, P < 0.05).CONCLUSION:
The SMSME-thin imaging technique enhanced the temporal-signal-to-noise ratio and functional activation at high susceptibility regions of the brain. J. Magn. Reson. Imaging 2016;44478-485.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Procesamiento de Señales Asistido por Computador
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Encéfalo
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Mapeo Encefálico
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Imagen por Resonancia Magnética
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Aumento de la Imagen
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Potenciales Evocados
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
J Magn Reson Imaging
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos