[Various pathways leading to the progression of chronic liver diseases]. / Az idült májbetegségek progressziójához vezeto folyamatok.
Orv Hetil
; 157(8): 290-7, 2016 Feb 21.
Article
en Hu
| MEDLINE
| ID: mdl-26876265
ABSTRACT
As the result of various effects (viruses, metabolic diseases, nutritional factors, toxic agents, autoimmune processes) abnormal liver function, liver steatosis and connective tissue remodeling may develop. Progression of this process is complex including various pathways and a number of factors. The authors summarize the factors involved in the progression of chronic liver disease. They describe the role of cells and the produced inflammatory mediators and cytokines, as well as the relationship between the disease and the intestinal flora. They emphasize the role of oxidative stress, mitochondrial dysfunction and cell death in disease progression. Insulin resistance and micro-elements (iron, copper) in relation to liver damage are also discussed, and genetic and epigenetic aspects underlying disease progression are summarized. Discovery of novel treatment options, assessment of the effectiveness of treatment, as well as the success and proper timing of liver transplantation may depend on a better understanding of the process of disease progression.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Oligoelementos
/
Resistencia a la Insulina
/
Mitocondrias Hepáticas
/
Citocinas
/
Estrés Oxidativo
/
Epigénesis Genética
/
Adipoquinas
/
Hepatopatías
Límite:
Humans
Idioma:
Hu
Revista:
Orv Hetil
Año:
2016
Tipo del documento:
Article