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Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis.
Matsumura, Hiroyuki; Mohri, Yasuaki; Binh, Nguyen Thanh; Morinaga, Hironobu; Fukuda, Makoto; Ito, Mayumi; Kurata, Sotaro; Hoeijmakers, Jan; Nishimura, Emi K.
Afiliación
  • Matsumura H; Department of Stem Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Mohri Y; Department of Stem Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Binh NT; Department of Stem Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan. Department of Stem Cell Medicine, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa 920-0934, Japan.
  • Morinaga H; Department of Stem Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Fukuda M; Department of Stem Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Ito M; Departments of Dermatology and Cell Biology, New York University School of Medicine, New York, NY, USA.
  • Kurata S; Beppu Garden-Hill Clinic, Kurata Clinic, Beppu city, Oita 8740831, Japan.
  • Hoeijmakers J; Department of Genetics, Cancer Genomics Center, Erasmus MC, Room Ee 722, Dr. Wytemaweg 80, 3015 CN Rotterdam, Netherlands.
  • Nishimura EK; Department of Stem Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan. nishscm@tmd.ac.jp.
Science ; 351(6273): aad4395, 2016 Feb 05.
Article en En | MEDLINE | ID: mdl-26912707

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Células Madre / Senescencia Celular / Folículo Piloso / Colágenos no Fibrilares / Alopecia / Proteolisis Límite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Science Año: 2016 Tipo del documento: Article País de afiliación: Japón

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Células Madre / Senescencia Celular / Folículo Piloso / Colágenos no Fibrilares / Alopecia / Proteolisis Límite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Science Año: 2016 Tipo del documento: Article País de afiliación: Japón