Harnessing the innate immune system to treat cancer: enhancement of antibody-dependent cellular cytotoxicity with anti-CD137 Ab.
Chin Clin Oncol
; 5(1): 5, 2016 Feb.
Article
en En
| MEDLINE
| ID: mdl-26932429
Palabras clave
CD137 is a costimulatory receptor that belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD137 is expressed on T cell, activated NK cells and other immune cells. We recently showed that an agonistic anti-CD137 mAb activates NK cells, resul; Efficacy of anti-CD137 mAb was examined by in vitro and in vivo experiments. Clinical trials of anti-CD137 mAb are also on-going.; Monoclonal antibodies are an invaluable therapeutic class when it comes to cancer therapy. One of the primary mechanisms of anti-tumor activity of monoclonal antibodies is antibody dependent cell-mediated cytotoxicity (ADCC) mediated by natural killer (NK; We discuss some of the promising strategies that could potentially enhance ADCC with anti-CD137 mAbs.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Miembro 9 de la Superfamilia de Receptores de Factores de Necrosis Tumoral
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Sistema Inmunológico
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Inmunoterapia
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Anticuerpos Monoclonales
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Citotoxicidad Celular Dependiente de Anticuerpos
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Neoplasias
Tipo de estudio:
Prognostic_studies
Límite:
Animals
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Humans
Idioma:
En
Revista:
Chin Clin Oncol
Año:
2016
Tipo del documento:
Article
País de afiliación:
Japón