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Meta-analysis of genome-wide association studies identifies three novel loci for saturated fatty acids in East Asians.
Zhu, Jingwen; Manichaikul, Ani; Hu, Yao; Chen, Yii-Der I; Liang, Shuang; Steffen, Lyn M; Rich, Stephen S; Tsai, Michael; Siscovick, David S; Lemaitre, Rozenn N; Li, Huaixing; Lin, Xu.
Afiliación
  • Zhu J; The Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China.
  • Manichaikul A; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
  • Hu Y; Department of Public Health Sciences, Division of Biostatistics and Epidemiology, University of Virginia, Charlottesville, VA, USA.
  • Chen YI; The Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China.
  • Liang S; Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA, USA.
  • Steffen LM; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
  • Rich SS; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
  • Tsai M; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
  • Siscovick DS; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
  • Lemaitre RN; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
  • Li H; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.
  • Lin X; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Eur J Nutr ; 56(4): 1477-1484, 2017 Jun.
Article en En | MEDLINE | ID: mdl-26932504
ABSTRACT

PURPOSE:

We aimed to characterize common genetic variants that influence saturated fatty acid concentrations in East Asians.

METHODS:

Meta-analysis of genome-wide association studies for circulating SFAs was conducted in two population-based cohorts comprising 3521 participants of Chinese ancestry.

RESULTS:

We identified two novel 140-associated loci at LMX1A (LIM homeobox transcription factor 1) and AMPD3 (AMP deaminase 3) (P = 5.08 × 10-9 and P = 4.33 × 10-8, respectively), and a novel 200-associated locus at CERS4 (ceramide synthase 4) (P = 1.76 × 10-10). We also confirmed the previously reported association of FADS1/2-rs102275 with 180 (P = 1.12 × 10-5). In addition, the A alleles of rs11042834 in AMPD3 and rs17159388 in CERS4 also exhibited evidence of associations with high-density lipoprotein cholesterol (P = 0.0162 and P = 0.0161, respectively).

CONCLUSIONS:

To our knowledge, this is the first GWAS analysis to examine SFA concentrations in East Asian populations. Our findings provide novel evidence that genetic variations of several genes from multiple pathways are associated with SFA concentrations in human body.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pueblo Asiatico / Estudio de Asociación del Genoma Completo / Ácidos Grasos / Sitios Genéticos Tipo de estudio: Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte / Asia Idioma: En Revista: Eur J Nutr Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2017 Tipo del documento: Article País de afiliación: China
Texto completo
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XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pueblo Asiatico / Estudio de Asociación del Genoma Completo / Ácidos Grasos / Sitios Genéticos Tipo de estudio: Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte / Asia Idioma: En Revista: Eur J Nutr Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2017 Tipo del documento: Article País de afiliación: China