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PET Imaging of Tau Deposition in the Aging Human Brain.
Schöll, Michael; Lockhart, Samuel N; Schonhaut, Daniel R; O'Neil, James P; Janabi, Mustafa; Ossenkoppele, Rik; Baker, Suzanne L; Vogel, Jacob W; Faria, Jamie; Schwimmer, Henry D; Rabinovici, Gil D; Jagust, William J.
Afiliación
  • Schöll M; Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, California, 94720, USA.
  • Lockhart SN; MedTech West and the Department of Clinical Neuroscience and Rehabilitation, University of Gothenburg, 405 30 Gothenburg, Sweden.
  • Schonhaut DR; Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, California, 94720, USA.
  • O'Neil JP; Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, California, 94158, USA.
  • Janabi M; Lawrence Berkeley National Laboratory, Berkeley, California, 94720, USA.
  • Ossenkoppele R; Lawrence Berkeley National Laboratory, Berkeley, California, 94720, USA.
  • Baker SL; Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, California, 94720, USA.
  • Vogel JW; Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, California, 94158, USA.
  • Faria J; Department of Neurology & Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, 1081 HV Amsterdam, The Netherlands.
  • Schwimmer HD; Lawrence Berkeley National Laboratory, Berkeley, California, 94720, USA.
  • Rabinovici GD; Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, California, 94720, USA.
  • Jagust WJ; Lawrence Berkeley National Laboratory, Berkeley, California, 94720, USA.
Neuron ; 89(5): 971-982, 2016 Mar 02.
Article en En | MEDLINE | ID: mdl-26938442
ABSTRACT
Tau pathology is a hallmark of Alzheimer's disease (AD) but also occurs in normal cognitive aging. Using the tau PET agent (18)F-AV-1451, we examined retention patterns in cognitively normal older people in relation to young controls and AD patients. Age and ß-amyloid (measured using PiB PET) were differentially associated with tau tracer retention in healthy aging. Older age was related to increased tracer retention in regions of the medial temporal lobe, which predicted worse episodic memory performance. PET detection of tau in other isocortical regions required the presence of cortical ß-amyloid and was associated with decline in global cognition. Furthermore, patterns of tracer retention corresponded well with Braak staging of neurofibrillary tau pathology. The present study defined patterns of tau tracer retention in normal aging in relation to age, cognition, and ß-amyloid deposition.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Encéfalo / Envejecimiento / Proteínas tau / Tomografía de Emisión de Positrones Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Encéfalo / Envejecimiento / Proteínas tau / Tomografía de Emisión de Positrones Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos