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Substituted 2-(2-aminopyrimidin-4-yl)pyridine-4-carboxylates as potent inhibitors of JumonjiC domain-containing histone demethylases.
Roatsch, Martin; Robaa, Dina; Pippel, Martin; Nettleship, Joanne E; Reddivari, Yamini; Bird, Louise E; Hoffmann, Inga; Franz, Henriette; Owens, Raymond J; Schüle, Roland; Flaig, Ralf; Sippl, Wolfgang; Jung, Manfred.
Afiliación
  • Roatsch M; Albert-Ludwigs-University Freiburg, Institute of Pharmaceutical Sciences, Albertstraße 25, 79104 Freiburg i.Br., Germany.
  • Robaa D; Martin-Luther-University Halle-Wittenberg, Institute of Pharmacy, Wolfgang-Langenbeck-Straße 4, 06120 Halle (Saale), Germany.
  • Pippel M; Martin-Luther-University Halle-Wittenberg, Institute of Pharmacy, Wolfgang-Langenbeck-Straße 4, 06120 Halle (Saale), Germany.
  • Nettleship JE; Oxford Protein Production Facility UK (OPPF-UK), Rutherford Appleton Laboratory, Harwell Science & Innovation Campus, Didcot, Oxfordshire, OX11 0FA, UK.
  • Reddivari Y; Oxford Protein Production Facility UK (OPPF-UK), Rutherford Appleton Laboratory, Harwell Science & Innovation Campus, Didcot, Oxfordshire, OX11 0FA, UK.
  • Bird LE; Oxford Protein Production Facility UK (OPPF-UK), Rutherford Appleton Laboratory, Harwell Science & Innovation Campus, Didcot, Oxfordshire, OX11 0FA, UK.
  • Hoffmann I; Albert-Ludwigs-University Freiburg, Institute of Pharmaceutical Sciences, Albertstraße 25, 79104 Freiburg i.Br., Germany.
  • Franz H; University Medical Center Freiburg, Central Clinical Research, Breisacher Straße 66, 79106 Freiburg i.Br., Germany.
  • Owens RJ; Oxford Protein Production Facility UK (OPPF-UK), Rutherford Appleton Laboratory, Harwell Science & Innovation Campus, Didcot, Oxfordshire, OX11 0FA, UK.
  • Schüle R; University Medical Center Freiburg, Central Clinical Research, Breisacher Straße 66, 79106 Freiburg i.Br., Germany.
  • Flaig R; Diamond Light Source, Harwell Science & Innovation Campus, Didcot, Oxfordshire, OX11 0DE, UK.
  • Sippl W; Martin-Luther-University Halle-Wittenberg, Institute of Pharmacy, Wolfgang-Langenbeck-Straße 4, 06120 Halle (Saale), Germany.
  • Jung M; Albert-Ludwigs-University Freiburg, Institute of Pharmaceutical Sciences, Albertstraße 25, 79104 Freiburg i.Br., Germany.
Future Med Chem ; 8(13): 1553-71, 2016 09.
Article en En | MEDLINE | ID: mdl-26971619
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirimidinas / Profármacos / Histona Demetilasas con Dominio de Jumonji / Inhibidores de Histona Desacetilasas / Ácidos Isonicotínicos Límite: Humans Idioma: En Revista: Future Med Chem Año: 2016 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Pirimidinas / Profármacos / Histona Demetilasas con Dominio de Jumonji / Inhibidores de Histona Desacetilasas / Ácidos Isonicotínicos Límite: Humans Idioma: En Revista: Future Med Chem Año: 2016 Tipo del documento: Article País de afiliación: Alemania