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Monocyte cell membrane-derived nanoghosts for targeted cancer therapy.
Krishnamurthy, S; Gnanasammandhan, M K; Xie, C; Huang, K; Cui, M Y; Chan, J M.
Afiliación
  • Krishnamurthy S; School of Chemical and Biomedical Engineering and Lee Kong Chian School of Medicine, Nanyang Technological University, Block N1.3, #B4-10, 70 Nanyang Drive, Singapore 637457. julianachan@ntu.edu.sg.
  • Gnanasammandhan MK; Department of Biomedical Engineering, National University of Singapore, 9 Engineering Drive 1, Block EA, #03-12, Singapore 117575.
  • Xie C; School of Chemical and Biomedical Engineering and Lee Kong Chian School of Medicine, Nanyang Technological University, Block N1.3, #B4-10, 70 Nanyang Drive, Singapore 637457. julianachan@ntu.edu.sg.
  • Huang K; Department of Biomedical Engineering, National University of Singapore, 9 Engineering Drive 1, Block EA, #03-12, Singapore 117575.
  • Cui MY; School of Chemical and Biomedical Engineering and Lee Kong Chian School of Medicine, Nanyang Technological University, Block N1.3, #B4-10, 70 Nanyang Drive, Singapore 637457. julianachan@ntu.edu.sg.
  • Chan JM; School of Chemical and Biomedical Engineering and Lee Kong Chian School of Medicine, Nanyang Technological University, Block N1.3, #B4-10, 70 Nanyang Drive, Singapore 637457. julianachan@ntu.edu.sg.
Nanoscale ; 8(13): 6981-5, 2016 Apr 07.
Article en En | MEDLINE | ID: mdl-26975904
ABSTRACT
Core-shell type 'nanoghosts' were synthesized with a drug-loaded biodegradable PLGA core and a monocyte cell membrane-derived shell. The nanoghosts were monodisperse with an average size <200 nm, and showed good serum stability for 120 h. Doxorubicin-loaded nanoghosts showed greater cellular uptake and cytotoxicity compared to non-coated nanoparticle controls in metastatic MCF-7 breast cancer cell lines.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ácido Poliglicólico / Monocitos / Membrana Celular / Sistemas de Liberación de Medicamentos / Ácido Láctico / Neoplasias Límite: Humans Idioma: En Revista: Nanoscale Año: 2016 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ácido Poliglicólico / Monocitos / Membrana Celular / Sistemas de Liberación de Medicamentos / Ácido Láctico / Neoplasias Límite: Humans Idioma: En Revista: Nanoscale Año: 2016 Tipo del documento: Article