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2,4,6-Triaminopyrimidine as a Novel Hinge Binder in a Series of PI3Kδ Selective Inhibitors.
Patel, Leena; Chandrasekhar, Jayaraman; Evarts, Jerry; Haran, Aaron C; Ip, Carmen; Kaplan, Joshua A; Kim, Musong; Koditek, David; Lad, Latesh; Lepist, Eve-Irene; McGrath, Mary E; Novikov, Nikolai; Perreault, Stephane; Puri, Kamal D; Somoza, John R; Steiner, Bart H; Stevens, Kirk L; Therrien, Joseph; Treiberg, Jennifer; Villaseñor, Armando G; Yeung, Arthur; Phillips, Gary.
Afiliación
  • Patel L; Gilead Sciences, Inc. , 199 E Blaine Street, Seattle, Washington 98102, United States.
  • Chandrasekhar J; Gilead Sciences, Inc. , 333 Lakeside Drive, Foster City, California 94404, United States.
  • Evarts J; Gilead Sciences, Inc. , 199 E Blaine Street, Seattle, Washington 98102, United States.
  • Haran AC; Gilead Sciences, Inc. , 333 Lakeside Drive, Foster City, California 94404, United States.
  • Ip C; Gilead Sciences, Inc. , 199 E Blaine Street, Seattle, Washington 98102, United States.
  • Kaplan JA; Gilead Sciences, Inc. , 333 Lakeside Drive, Foster City, California 94404, United States.
  • Kim M; Gilead Sciences, Inc. , 199 E Blaine Street, Seattle, Washington 98102, United States.
  • Koditek D; Gilead Sciences, Inc. , 333 Lakeside Drive, Foster City, California 94404, United States.
  • Lad L; Gilead Sciences, Inc. , 199 E Blaine Street, Seattle, Washington 98102, United States.
  • Lepist EI; Gilead Sciences, Inc. , 333 Lakeside Drive, Foster City, California 94404, United States.
  • McGrath ME; Gilead Sciences, Inc. , 199 E Blaine Street, Seattle, Washington 98102, United States.
  • Novikov N; Gilead Sciences, Inc. , 333 Lakeside Drive, Foster City, California 94404, United States.
  • Perreault S; Gilead Sciences, Inc. , 199 E Blaine Street, Seattle, Washington 98102, United States.
  • Puri KD; Gilead Sciences, Inc. , 333 Lakeside Drive, Foster City, California 94404, United States.
  • Somoza JR; Gilead Sciences, Inc. , 199 E Blaine Street, Seattle, Washington 98102, United States.
  • Steiner BH; Gilead Sciences, Inc. , 333 Lakeside Drive, Foster City, California 94404, United States.
  • Stevens KL; Gilead Sciences, Inc. , 199 E Blaine Street, Seattle, Washington 98102, United States.
  • Therrien J; Gilead Sciences, Inc. , 333 Lakeside Drive, Foster City, California 94404, United States.
  • Treiberg J; Gilead Sciences, Inc. , 199 E Blaine Street, Seattle, Washington 98102, United States.
  • Villaseñor AG; Gilead Sciences, Inc. , 333 Lakeside Drive, Foster City, California 94404, United States.
  • Yeung A; Gilead Sciences, Inc. , 199 E Blaine Street, Seattle, Washington 98102, United States.
  • Phillips G; Gilead Sciences, Inc. , 333 Lakeside Drive, Foster City, California 94404, United States.
J Med Chem ; 59(7): 3532-48, 2016 Apr 14.
Article en En | MEDLINE | ID: mdl-26980109
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Artritis Experimental / Pirimidinas / Inhibidores de Proteínas Quinasas / Quinazolinonas / Fosfatidilinositol 3-Quinasa Clase I Límite: Animals / Female / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Artritis Experimental / Pirimidinas / Inhibidores de Proteínas Quinasas / Quinazolinonas / Fosfatidilinositol 3-Quinasa Clase I Límite: Animals / Female / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos