Chronic osteomyelitis increases long-term mortality risk in the elderly: a nationwide population-based cohort study.
BMC Geriatr
; 16: 72, 2016 Mar 31.
Article
en En
| MEDLINE
| ID: mdl-27029408
ABSTRACT
BACKGROUND:
The elderly are predisposed to chronic osteomyelitis because of the immunocompromised nature of aging and increasing number of chronic comorbidities. Chronic osteomyelitis may significantly affect the health of the elderly; however, its impact on long-term mortality remains unclear. We conceived this retrospective nationwide population-based cohort study to address this issue.METHODS:
We identified 10,615 elderly patients (≥65 years) comprising 965 patients with chronic osteomyelitis and 9650 without chronic osteomyelitis matched at a ratio of 110 by age and gender between 1999 and 2010 from the Taiwan National Health Insurance Research Database. The risk of chronic osteomyelitis between the two cohorts was compared by a following-up until 2011.RESULTS:
Patients with chronic osteomyelitis had a significantly higher mortality risk than those without chronic osteomyelitis [incidence rate ratio (IRR) 2.29; 95 % confidence interval (CI) 2.01-2.59], particularly the old elderly (≥85 years; IRR 3.27; 95 % CI 2.22-4.82) and males (IRR 2.7; 95 % CI 2.31-3.16). The highest mortality risk was observed in the first month (IRR 5.01; 95 % CI 2.02-12.42), and it remained persistently higher even after 6 years (IRR 1.53; 95 % CI 1.13-2.06) of follow-up. Cox proportional hazard regression analysis showed that chronic osteomyelitis [adjusted hazard ratio (AHR) 1.89; 95 % CI 1.66-2.15], advanced age (≥85 years; AHR 2.02; 95 % CI 1.70-2.41), male (AHR 1.34; 95 % CI 1.22-1.48), and chronic comorbidities were independent predictors of mortality.CONCLUSIONS:
This study demonstrated that chronic osteomyelitis significantly increased the long-term mortality risk in the elderly. Therefore, strategies for prevention and treatment of chronic osteomyelitis and concomitant control of chronic comorbidities are very important for the management of the elderly, particularly for a future with an increasingly aged population worldwide.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Osteomielitis
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
BMC Geriatr
Asunto de la revista:
GERIATRIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Taiwán