Embryonic heart mesenchymal cell migration in laminin.
Dev Biol
; 133(1): 37-43, 1989 May.
Article
en En
| MEDLINE
| ID: mdl-2707485
ABSTRACT
Laminin, a large glycoprotein and major component of basement membranes, influences cell adhesion, migration, morphology, and differentiation. A peptide sequence, YIGSR, from the B1 chain of laminin has been found to correspond to an active site for cell adhesion. We report here that cardiac mesenchymal cells migrate vigorously within three-dimensional gels of laminin and that the YIGSR peptide will completely abolish this migratory activity. In contrast, migration of the mesenchymal cells into three-dimensional gels composed of collagen or collagen + laminin is not effected by YIGSR or other peptides (GRGDS, GRGDTP) reported to mediate cellular adhesion.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Laminina
/
Corazón
/
Mesodermo
Límite:
Animals
Idioma:
En
Revista:
Dev Biol
Año:
1989
Tipo del documento:
Article