Quantitative blood oxygen saturation imaging using combined photoacoustics and acousto-optics.
Opt Lett
; 41(8): 1720-3, 2016 Apr 15.
Article
en En
| MEDLINE
| ID: mdl-27082328
ABSTRACT
In photoacoustic spectroscopy (PAS), wavelength dependent optical attenuation of biological tissue presents a challenge to measure the absolute oxygen saturation of hemoglobin (sO2). Here, we employ the combination of photoacoustics and acousto-optics (AO) at two optical wavelengths to achieve quantification, where AO serves as a sensor for the relative local fluence. We demonstrate that our method enables compensation of spatial as well as wavelength dependent fluence variations in PAS without a priori knowledge about the optical properties of the medium. The fluence compensated photoacoustic images at two excitation wavelengths are used to estimate the absolute oxygen saturation of blood in a spatially and spectroscopically heterogeneous phantom.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Oxígeno
/
Acústica
/
Técnicas Fotoacústicas
/
Imagen Óptica
Límite:
Humans
Idioma:
En
Revista:
Opt Lett
Año:
2016
Tipo del documento:
Article