Four-Dimensional Dose Reconstruction for Scanned Proton Therapy Using Liver 4DCT-MRI.
Int J Radiat Oncol Biol Phys
; 95(1): 216-223, 2016 May 01.
Article
en En
| MEDLINE
| ID: mdl-27084643
ABSTRACT
PURPOSE:
Four-dimensional computed tomography-magnetic resonance imaging (4DCT-MRI) is an image-processing technique for simulating many 4DCT data sets from a static reference CT and motions extracted from 4DMRI studies performed using either volunteers or patients. In this work, different motion extraction approaches were tested using 6 liver cases, and a detailed comparison between 4DCT-MRI and 4DCT was performed. METHODS AND MATERIALS 4DCT-MRI has been generated using 2 approaches. The first approach used motion extracted from 4DMRI as being "most similar" to that of 4DCT from the same patient (subject-specific), and the second approach used the most similar motion obtained from a motion library derived from 4DMRI liver studies of 13 healthy volunteers (population-based). The resulting 4DCT-MRI and 4DCTs were compared using scanned proton 4D dose calculations (4DDC).RESULTS:
Dosimetric analysis showed that 93% ± 8% of points inside the clinical target volume (CTV) agreed between 4DCT and subject-specific 4DCT-MRI (gammaanalysis:
3%/3 mm). The population-based approach however showed lower dosimetric agreement with only 79% ± 14% points in the CTV reaching the 3%/3 mm criteria.CONCLUSIONS:
4D CT-MRI extends the capabilities of motion modeling for dose calculations by accounting for realistic and variable motion patterns, which can be directly employed in clinical research studies. We have found that the subject-specific liver modeling appears more accurate than the population-based approach. The former is particularly interesting for clinical applications, such as improved target delineation and 4D dose reconstruction for patient-specific QA to allow for inter- and/or intra-fractional plan corrections.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Procesamiento de Imagen Asistido por Computador
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Imagen por Resonancia Magnética
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Tomografía Computarizada Cuatridimensional
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Imagen Multimodal
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Terapia de Protones
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Hígado
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Movimiento
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Int J Radiat Oncol Biol Phys
Año:
2016
Tipo del documento:
Article