Antibacterial Meroterpenoids from the South China Sea Sponge Dysidea sp.
Chem Pharm Bull (Tokyo)
; 64(7): 1036-42, 2016 Jul 01.
Article
en En
| MEDLINE
| ID: mdl-27109501
ABSTRACT
Chemical investigation of the sponge Dysidea sp. afforded three new sesquiterpene phenols (1-3) and one new sesquiterpene aminoquinone (4), together with four known sesquiterpene derivatives (5-8). The structures of all compounds were unambiguously elucidated by extensive spectroscopic analysis, as well as by comparison with the literature. The absolute configurations of compounds 1-4 were determined by electron capture detector (ECD) calculations and circular dichroism (CD) spectrum analysis. Their antibacterial activity against Escherichia coli (25922), Bacillus subtilis (6633), and Staphylococcus aureus (25923) were evaluated. Compounds 1 and 3 showed weak antibacterial activity against the above three strains, whereas compounds 4-8 showed potent antibacterial activities with minimum inhibitory concentration (MIC) values in the range of 3.125 to 12.5 µg/mL.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Staphylococcus aureus
/
Terpenos
/
Bacillus subtilis
/
Dysidea
/
Escherichia coli
/
Antibacterianos
Límite:
Animals
País/Región como asunto:
Asia
Idioma:
En
Revista:
Chem Pharm Bull (Tokyo)
Año:
2016
Tipo del documento:
Article