Atractylenolide I modulates ovarian cancer cell-mediated immunosuppression by blocking MD-2/TLR4 complex-mediated MyD88/NF-&#954;B signaling in vitro.

Liu, Hong; Zhang, Guonan; Huang, Jianming; Ma, Shiqi; Mi, Kun; Cheng, Jia; Zhu, Yi; Zha, Xiao; Huang, Wei

Atractylenolide I modulates ovarian cancer cell-mediated immunosuppression by blocking MD-2/TLR4 complex-mediated MyD88/NF-κB signaling in vitro.

Liu, Hong; Zhang, Guonan; Huang, Jianming; Ma, Shiqi; Mi, Kun; Cheng, Jia; Zhu, Yi; Zha, Xiao; Huang, Wei.

Afiliación

Liu H; Department of Obstetrics and Gynecology, West China Second University Hospital of Sichuan University, No. 20, Section 3 of South People's Road, Chengdu, 610041, China.
Zhang G; Department of Gynecologic Oncology, Sichuan Cancer Hospital, No.55, Section 4 of South People's Road, Chengdu, 610041, China.
Huang J; Department of Gynecologic Oncology, Sichuan Cancer Hospital, No.55, Section 4 of South People's Road, Chengdu, 610041, China.
Ma S; Department of Biochemistry and Molecular Biology, Sichuan Cancer Institute, No.55, Section 4 of South People's Road, Chengdu, 610041, China.
Mi K; Department of Biochemistry and Molecular Biology, Sichuan Cancer Institute, No.55, Section 4 of South People's Road, Chengdu, 610041, China.
Cheng J; Department of Biochemistry and Molecular Biology, Sichuan Cancer Institute, No.55, Section 4 of South People's Road, Chengdu, 610041, China.
Zhu Y; Department of Biochemistry and Molecular Biology, Sichuan Cancer Institute, No.55, Section 4 of South People's Road, Chengdu, 610041, China.
Zha X; Department of Gynecologic Oncology, Sichuan Cancer Hospital, No.55, Section 4 of South People's Road, Chengdu, 610041, China.
Huang W; Department of Ultrasound, Sichuan Cancer Hospital, No.55, Section 4 of South People's Road, Chengdu, 610041, China.

J Transl Med ; 14(1): 104, 2016 04 27.

Article en En | MEDLINE | ID: mdl-27118139

Asunto(s)

Terapia de Inmunosupresión; Lactonas/farmacología; Antígeno 96 de los Linfocitos/metabolismo; Factor 88 de Diferenciación Mieloide/metabolismo; FN-kappa B/metabolismo; Neoplasias Ováricas/inmunología; Sesquiterpenos/farmacología; Receptor Toll-Like 4/metabolismo; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Citocinas/metabolismo; Citotoxicidad Inmunológica/efectos de los fármacos; Regulación hacia Abajo/efectos de los fármacos; Femenino; Humanos; Indolamina-Pirrol 2,3,-Dioxigenasa/metabolismo; Quinurenina/farmacología; Neoplasias Ováricas/patología; Proteínas Proto-Oncogénicas c-akt/metabolismo; Transducción de Señal/efectos de los fármacos; Linfocitos T/efectos de los fármacos

Palabras clave

Atractylenolide I; Epithelial ovarian cancer; Immunosuppressive cytokines; Indoleamine 2,3-dioxygenase; MyD88/NF-κB signaling; TLR4/MD-2 complex

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Sesquiterpenos / FN-kappa B / Terapia de Inmunosupresión / Antígeno 96 de los Linfocitos / Receptor Toll-Like 4 / Factor 88 de Diferenciación Mieloide / Lactonas Límite: Female / Humans Idioma: En Revista: J Transl Med Año: 2016 Tipo del documento: Article País de afiliación: China

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google