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Targeting epigenetic reader and eraser: Rational design, synthesis and in vitro evaluation of dimethylisoxazoles derivatives as BRD4/HDAC dual inhibitors.
Zhang, Zhimin; Hou, Shaohua; Chen, Hongli; Ran, Ting; Jiang, Fei; Bian, Yuanyuan; Zhang, Dewei; Zhi, Yanle; Wang, Lu; Zhang, Li; Li, Hongmei; Zhang, Yanmin; Tang, Weifang; Lu, Tao; Chen, Yadong.
Afiliación
  • Zhang Z; Department of Organic Chemistry, School of Science, 639 Longmian Avenue, Nanjing 211198, China.
  • Hou S; Department of Organic Chemistry, School of Science, 639 Longmian Avenue, Nanjing 211198, China.
  • Chen H; Department of Organic Chemistry, School of Science, 639 Longmian Avenue, Nanjing 211198, China.
  • Ran T; Laboratory of Molecular Design and Drug Discovery, School of Science, 639 Longmian Avenue, Nanjing 211198, China.
  • Jiang F; Department of Organic Chemistry, School of Science, 639 Longmian Avenue, Nanjing 211198, China.
  • Bian Y; Department of Organic Chemistry, School of Science, 639 Longmian Avenue, Nanjing 211198, China.
  • Zhang D; Department of Organic Chemistry, School of Science, 639 Longmian Avenue, Nanjing 211198, China.
  • Zhi Y; Department of Organic Chemistry, School of Science, 639 Longmian Avenue, Nanjing 211198, China.
  • Wang L; Department of Organic Chemistry, School of Science, 639 Longmian Avenue, Nanjing 211198, China.
  • Zhang L; Department of Organic Chemistry, School of Science, 639 Longmian Avenue, Nanjing 211198, China.
  • Li H; Department of Organic Chemistry, School of Science, 639 Longmian Avenue, Nanjing 211198, China.
  • Zhang Y; Laboratory of Molecular Design and Drug Discovery, School of Science, 639 Longmian Avenue, Nanjing 211198, China.
  • Tang W; Department of Organic Chemistry, School of Science, 639 Longmian Avenue, Nanjing 211198, China.
  • Lu T; Laboratory of Molecular Design and Drug Discovery, School of Science, 639 Longmian Avenue, Nanjing 211198, China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China. Electronic address: lutao@cpu.edu.cn.
  • Chen Y; Laboratory of Molecular Design and Drug Discovery, School of Science, 639 Longmian Avenue, Nanjing 211198, China. Electronic address: ydchen@cpu.edu.cn.
Bioorg Med Chem Lett ; 26(12): 2931-2935, 2016 06 15.
Article en En | MEDLINE | ID: mdl-27142751
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Factores de Transcripción / Proteínas Nucleares / Diseño de Fármacos / Epigénesis Genética / Inhibidores de Histona Desacetilasas / Histona Desacetilasas / Isoxazoles / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Factores de Transcripción / Proteínas Nucleares / Diseño de Fármacos / Epigénesis Genética / Inhibidores de Histona Desacetilasas / Histona Desacetilasas / Isoxazoles / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: China