Understanding the genetics of APOE and TOMM40 and role of mitochondrial structure and function in clinical pharmacology of Alzheimer's disease.

Roses, Allen; Sundseth, Scott; Saunders, Ann; Gottschalk, William; Burns, Dan; Lutz, Michael

Understanding the genetics of APOE and TOMM40 and role of mitochondrial structure and function in clinical pharmacology of Alzheimer's disease.

Roses, Allen; Sundseth, Scott; Saunders, Ann; Gottschalk, William; Burns, Dan; Lutz, Michael.

Afiliación

Roses A; Department of Neurology, Duke University School of Medicine, Durham, NC, USA; Semillon Pharmaceuticals, Inc., Chapel Hill, NC, USA. Electronic address: allen.roses@duke.edu.
Sundseth S; Department of Neurology, Duke University School of Medicine, Durham, NC, USA; Semillon Pharmaceuticals, Inc., Chapel Hill, NC, USA.
Saunders A; Department of Neurology, Duke University School of Medicine, Durham, NC, USA; Semillon Pharmaceuticals, Inc., Chapel Hill, NC, USA.
Gottschalk W; Department of Neurology, Duke University School of Medicine, Durham, NC, USA; Semillon Pharmaceuticals, Inc., Chapel Hill, NC, USA.
Burns D; Department of Neurology, Duke University School of Medicine, Durham, NC, USA; Semillon Pharmaceuticals, Inc., Chapel Hill, NC, USA.
Lutz M; Department of Neurology, Duke University School of Medicine, Durham, NC, USA; Semillon Pharmaceuticals, Inc., Chapel Hill, NC, USA.

Alzheimers Dement ; 12(6): 687-94, 2016 06.

Article en En | MEDLINE | ID: mdl-27154058

Asunto(s)

Enfermedad de Alzheimer/genética; Enfermedad de Alzheimer/patología; Apolipoproteínas E/genética; Predisposición Genética a la Enfermedad/genética; Proteínas de Transporte de Membrana/genética; Mitocondrias/patología; Estudio de Asociación del Genoma Completo; Humanos; Desequilibrio de Ligamiento; Mitocondrias/genética; Proteínas del Complejo de Importación de Proteínas Precursoras Mitocondriales; Polimorfismo de Nucleótido Simple/genética

Palabras clave

APOE; Alzheimer's disease short structural variations [SSVs]; Genetics; Mitochondria; Phylogenetic mapping; Sequencing; TOMM40

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Apolipoproteínas E / Proteínas de Transporte de Membrana / Predisposición Genética a la Enfermedad / Enfermedad de Alzheimer / Mitocondrias Límite: Humans Idioma: En Revista: Alzheimers Dement Año: 2016 Tipo del documento: Article

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